Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000443
Title: Formulation and release kinetic study of Hydrogel containing Acarbose using polymers as Hydroxypropylmethyl cellulose and Guar gum
Category: Pharmaceutics
Section: Research Article
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    Hydrogel matrix tablets of Acarbose was formulated using hydroxypropyl methyl cellulose and guar gum with the aim to study of release kinetic and to attain a near zero order release. In-vitro dissolution studies were carried out using USP type 2 dissolution test apparatus. The release of drug followed a typical Higuchian pattern. Matrix tablets formulated employing hydroxypropyl methyl cellulose and guar gum slow release of Acarbose over a period of 12 h and were found suitable for maintenance portion of oral controlled release tablets. Acarbose release from these tablets were diffusion controlled and followed zero order kinetics after a lag time of 1h.The most successful of the study, exhibited drug release pattern very close to theoretical release profile. A decrease in release kinetics of the drug was observed on increasing polymer ratio.

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    Author(s) Name:

    G.Kumar1*,V.Juyal2, P.P.Badoni3, M.S.M.Rawat4 , A.Semalty5

    Affiliation(s) Name:

    *1 Department of Pharmacy, S.G.R.R.I.T.S. Patelnagar, Dehradun -248001, India
    2 Department of Pharmaceutical Sciences, Kumaon University, Bhimtal, (UA)
    3 Department of Chemistry, H.N.B. Garhwal University, Pauri Campus (UA)
    4 Department of Chemistry, H.N.B. University, Srinagar (UA) – 246174
    5 Department of Pharmaceutical Sciences, Garhwal University, Srinagar, (UA)


    For correspondence:Ganesh Kumar,Department of Pharmacy,S.G.R.R.I.T.S. Patel nagar, Dehradun,Uttrakhand, India ,Pin- 248001

    Received on:23-09-2008; Accepted on :04-01-2009

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    Author:

    G.Kumar1*,V.Juyal2, P.P.Badoni3, M.S.M.Rawat4 , A.Semalty5

    Title:Formulation and release kinetic study of Hydrogel containing Acarbose using polymers as Hydroxypropylmethyl cellulose and Guar gum
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (March)
    Year:2009
    Page No: (370-374)
  • Experimental Methods Keywords

    Methodology:Formulation and release kinetic study
    Research Materials:Hydrogel matrix tablets

Keywords

Formulation ;release kinetic study ; Hydrogel ; Hydroxypropylmethyl cellulose;Guar gum

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