Journal: Journal of Pharmacy Research

Article Id: JPRS-PHDRS-0000447
Title: Effect of ethanol extract of fruits of Passiflora foetida Linn. on CCl4 induced hepatic injury in rats
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
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    Hepatoprotective activity of ethanolic extract of fruits of Passiflora foetida was studied against CCl4 induced hepatic injury in albino rats. Pretreatment of ethanolic extract (EPF 200 mg/kg/day, p.o.) significantly (p<0.001) reduced the biochemical markers of hepatic injury like serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), total bilirubin and gamma glutamate transpeptidase (GGTP). Histopathological observations also revealed that pretreatment with EPF protected the animals from CCl4 induced liver damage. The results indicate that the fruits of P. foetida possess hepatoprotective activity. This property may be attributed to the flavonoids present in the fruits of P. foetida.

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    Author(s) Name:

    Ramasamy Anandan1, Balasundaram Jayakar1, Sundararaman Jeganathan2 , Rajappan Manavalan2 and Raju Senthil Kumar3*

    Affiliation(s) Name:

    1 Vinayaka Mission’s College of Pharmacy, Salem – 636 008, Tamilnadu, India.
    2 Department of Pharmacy, Annamalai Univeristy, Chidambaram, Tamilnadu, India.
    *3 Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengodu- 637 205, Tamilnadu, India.


    For correspondence:Raju Senthil Kumar ,Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengodu- 637 205, Tamilnadu, India.

    Received on:11-12-2008; Accepted on :04-02-2009

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    Author:

    Ramasamy Anandan1, Balasundaram Jayakar1, Sundararaman Jeganathan2 , Rajappan Manavalan2 and Raju Senthil Kumar3*

    Title:Effect of ethanol extract of fruits of Passiflora foetida Linn. on CCl4 induced hepatic injury in rats
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (March)
    Year:2009
    Page No: (413-415)
  • Experimental Methods Keywords

    Methodology:hepatoprotective, carbon tetrachloride, biochemical parameters, histopathological studies
    Research Materials:Passiflora foetida

Keywords

Passiflora foetida hepatoprotective carbon tetrachloride biochemical parameters histopathological studies

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