Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004474
Title: The sensitivity and specificity of available Helicobacter pylori diagnosis techniques considering the emerging multidrug resistance
Category: Pharmacology
Section: Research Article
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    Aim: Helicobacter pylori is a ubiquitous organism that is present in about 50% of the global population. Chronic infection with H. pylori causes atrophic and even metaplastic changes in the stomach, and it has a known association with peptic ulcer disease. H. pylori causes chronic gastritis and has been associated with several serious diseases of the gastrointestinal tract including duodenal ulcer and gastric cancer. The aim of this study is to determine the comparison between the sensitivity and specificity of these methods and their application and also study the antibiotic resistance appearing in H. pylori. Materials and Method: H. pylori infection can be diagnosed by invasive techniques requiring endoscopy and biopsy (e.g., histological examination, culture, and rapid urease test) and by non-invasive techniques such as serology, the urea breath test, urine/blood, or detection of H. pylori antigen in stool specimen. Non-invasive test-and-treat strategies are widely recommended in the primary care setting. The choice of appropriate test depends on the pre-test probability of infection, the characteristics of the test being used and its cost-effectiveness. Antimicrobial resistance is a growing problem in H. pylori treatment. A very high percentage of patients were infected with metronidazole- and clarithromycin-resistant strains. This research will be carried out in several hospitals and private laboratory in Jordan. Results: The results showed that the highest sensitivity was using tissue samples and resistance to clarithromycin, metronidazole, and other antibiotics is mostly due to the use of these drugs for infectious diseases other than H. pylori infection. Conclusion: Furthermore, false-negative results may occur following a new infection before the antibody level is sufficiently elevated.

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    Author(s) Name:

    Nawal S. Faris*, Safaa Al-Zeidaneen, Hashem A. Abu-Huriarh, Mohammad M. Hadieh, Omar M. Hadieh

    Affiliation(s) Name:

    Department of Allied Medical Sciences, Al-Zarqa University College, Zarqa University, Zarqa, Jordan

    *Corresponding author: Dr. Nawal S. Faris, Department of Allied Medical Sciences, Al-Zarqa University College, Zarqa University, Zarqa, Jordan.

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    Author:

    Nawal S. Faris*, Safaa Al-Zeidaneen, Hashem A. Abu-Huriarh, Mohammad M. Hadieh, Omar M. Hadieh

    Title:The sensitivity and specificity of available Helicobacter pylori diagnosis techniques considering the emerging multidrug resistance
    Journal:Drug Invention Today
    Vol(issue):12 (November )
    Year:2019
    Page No: (2736-2740)
  • Experimental Methods Keywords

    Methodology:Sensitivity, Specificity diagnosis techniques and drug resistance
    Research Materials:H. pylori infection

Keywords

Helicobacter pylori Sensitivity Specificity diagnosis techniques and drug resistance

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