Journal: Journal of Pharmacy Research

Article Id: JPRS-PHDRS-0000448
Title: Evaluation of anti-histaminic activity ofaqueous extract of ripe olives of olea-europea
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
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    According to Ayurveda, Olea europea is used in treatment of leprosy, dysentery, vaginal and uterine complaints, inflammation, burning sensation, fatigue, asthma, leucoderma etc. In the present study the histamine induced dose dependent contraction of goat tracheal chain and guinea pig ileum preparation was significantly inhibited (p< 0.01) by the aqueous extract of leaves of Olea europea (800 ug/ml and 100 ug/ml). Olea europea at the doses of 100and 200 mg/kg,i.p.,exhibited significant (p< 0.01) mast cell stabilizing activity against clonidine induced peritoneal mast cell degranulation in rats. Prior treatment with Olea europea extract (6.6 mg/kg and 10.2 mg/kg, i.p) significantly inhibited the clonidine-induced catalepsy in mice but, did not show any significant decrease in haloperidol induced catalepsy. Thus the present study revealed that the extract of olives of Olea europea has significant antihistaminic (H1 receptor antagonist) activity.

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    Author(s) Name:

    Raman Chandak*, Subhash Devdhe, Vaibhav Changediya

    Affiliation(s) Name:

    Central Drug Research Institute (CDRI), Lucknow-226001

    *Yash Institute of Pharmacy, Aurangabad-431134


    For correspondence:Raman Chandak ,Department of Pharmacognosy,Yash Institute of Pharmacy, Aurangabad-431134

    Received on:15-09-2008; Accepted on :15-01-2009

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    Author:

    Raman Chandak*, Subhash Devdhe, Vaibhav Changediya

    Title:Evaluation of anti-histaminic activity ofaqueous extract of ripe olives of olea-europea
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (March)
    Year:2009
    Page No: (416-420)
  • Experimental Methods Keywords

    Methodology:anti-histaminic activity
    Research Materials:Olea europea

Keywords

Olea europea anti-histaminic activity

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