Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004480
Title: Effect of xylitol-containing chewing gum on bacterial load in saliva
Category: Pharmacology
Section: Research Article
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    Introduction: Xylitol is a white crystalline five-carbon sugar polyol obtained naturally. It has been extensively studied during the past 40 years for its effect on dental caries. Xylitol reduces the levels of Streptococcus mutans (MS) in saliva and plaque by disturbing their energy production processes, which leads to futile energy cycle and eventually cell death. It reduces the adhesion of microorganisms to the teeth surface and also reduces their acid production potential. Xylitol reduces the incidence of dental caries by increasing salivary flow and buffering the pH. The predominant modality for xylitol delivery is being chewing gum. The plaque samples of habitual xylitol users showed a significant reduction in plaque adhesiveness and insoluble extracellular polysaccharides produced by MS when compared with those who did not consume xylitol at all. Materials and Methods: The study is done to assess the reduction in the total bacterial load in the saliva after chewing xylitol-containing gum for a period of 7 days. Twenty-five individuals were selected randomly. Xylitol containing chewing gums were procured. About 14 chewing gums were given to the subjects and asked to take once in the morning and once in the evening for 7 days. Samples collected were subjected for microbiological examination. The saliva samples were diluted at the ratio of 1:80 using sterile normal saline in a sterile cuvette. Then, it is made as a uniform suspension by manual agitation. From this, 10 µl is pipetted and transferred to the surface of brain heart infusion agar. The plates were incubated for 24 h at 37°C aerobically. After the incubation, the plates were examined for bacterial growth and the total bacterial count was done manually and tabulated. Discussion: In this study, it was observed that the percentage decrease was 78.31% within 7 days of using xylitol chewing gum. In this study, it was found that the total bacterial load is reduced by chewing gum. Although it is a transient change, long-term usage will definitely improve the overall health of the mouth, whereby decreasing the risk of cariogenesis and other types of lesions in the mouth. Conclusion: Xylitol is a naturally occurring sugar that prevents caries. This study was done to find out its anticariogenic property. With the positive outcome it concluded that xylitol-containing gums can be used to prevent caries. As per the previous studies, the 5–6 g of xylitol can be used without any adverse effect on long-term basis.

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    Author(s) Name:

    S. M. Azima Hanin, N. P. Muralidharan*

    Affiliation(s) Name:

    Department of Microbiology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: N. P. Muralidharan, Department of Microbiology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

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    Author:

    S. M. Azima Hanin, N. P. Muralidharan*

    Title:Effect of xylitol-containing chewing gum on bacterial load in saliva
    Journal:Drug Invention Today
    Vol(issue):11 (October [Special Issue 1])
    Year:2019
    Page No: (171-174)
  • Experimental Methods Keywords

    Methodology: Total bacterial count
    Research Materials:Chewing gum, Xylitol

Keywords

Bacterial load Chewing gum Saliva Xylitol

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