Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000450
Title: Formulation and Evaluation of Novel FDCs of Antitubercular Drugs
Category: Pharmaceutics
Section: Research Article
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    The objective of the present study was to formulate and evaluate novel FDCs of antitubercular drugs. The solid mixtures of rifampicin and sodium lauryl sulphate were prepared at molar ratio of 1:1 by co-grinding method. Characterization of Rifampicin-SLS mixture was performed using DSC, XRD and FTIR studies. In vitro dissolution studies were carried out in 0.1N HCl and phosphate buffer pH 6.8. Solid mixtures prepared by co-grinding method were found to be useful in delaying the dissolution of rifampicin in acidic medium in molar ratio 1:1.The release of rifampicin from novel fixed dose combination formulation was 0% in 0.1N HCl up to two hours and faster release within 15 minutes in alkaline pH was achieved, while Isoniazid was released completely within 20 minutes in 0.1 N HCl. A novel formulation comprising of rifampicin and sodium lauryl sulphate, prepared by co-grinding method proved effective to minimize the degradation of rifampicin in acidic environment by its retarded release pattern. Thus this approach is beneficial for the segregation of release pattern of rifampicin in alkaline environment and isoniazid in the acidic environment of the GI tract, which will lead to prevent the degradation of rifampicin alone & its interaction with isoniazid.

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    Author(s) Name:

    Satish Balkrishna Bhise*1, Sevukarajan Mookkan1

    Affiliation(s) Name:

    *1Department of Biopharmaceutics, Government College of pharmacy, Karad, 415124, India


    For correspondence:Satish Balkrishna Bhise,Department of Biopharmaceutics, Government College of pharmacy, Karad, 415124, India

    Received on:16-10-2008; Accepted on :24-02-2009

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    Author:

    Satish Balkrishna Bhise*1, Sevukarajan Mookkan1

    Title:Formulation and Evaluation of Novel FDCs of Antitubercular Drugs
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (March)
    Year:2009
    Page No: (437-444)
  • Experimental Methods Keywords

    Methodology:Formulation and Evaluation
    Research Materials:Rifampicin

Keywords

Rifampicin Sodium lauryl sulphate co-grinding delayed release isoniazid

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