Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000451
Title: Formulation and optimization of controlled released floating tablets of clarithromycin
Category: Pharmaceutics
Section: Research Article
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  • Abstract

    Floating matrix tablets are designed to prolong the gastric residence time after oral administration, at a particular site and controlling the release of drug especially useful for achieving controlled plasma level as well as improving bioavailability. With this objective, controlled release floating tablets of clarithromycin were formulated by using D-optimal mixture design for the treatment of Helicobacter pylori. The amount of HPMC K4M: HPMC K100LV in 1:1 ratio (X1), amount of Na- CMC (X2) and amount of sodium bicarbonate (X3) were selected as independent variables and percentage drug release at 3h (Y1), percentage drug release at 6h(Y2), percentage drug release at 12h (Y3) and total floating lag time (Y4) as dependent variables. Tablets containing HPMC K4M and HPMC K100LV, drug and different additives were prepared by wet granulation. The tablet composition and mechanical strength have great influence on the floating properties and drug release. Optimization of the evaluating parameters with Design expert software was employed to generate optimized formulation and criteria of desirability was employed. The optimized formulation was obtained with HPMC K4M: HPMC K100LV in 1:1 ratio (125.428 mg), Na-CMC (40.256 mg) and sodium bicarbonate (34.316 mg). The in vitro release data showed that the drug release follows zero-order release kinetics.

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    Author(s) Name:

    Shashikant D. Barhate*1, Dr. Madhabhai M. Patel2, Amol B. Patil, Sandeep R. Pawar and Sumit R. Rathi.

    Affiliation(s) Name:

    *1Department of Pharmaceutics, Smt. S. S. Patil College of Pharmacy, Chopda- 425107. Maharashtra.
    2 Principal, Kalol Institute of Pharmacy, Kalol -382721. Gujarat.


    For correspondence:Prof. Shashikant D. Barhate, Department of Pharmaceutics, Smt. S. S. Patil College of Pharmacy, Chopda- 425107. Maharashtra.


    Received on:17-10-2008; Accepted on :26-01-2009

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    Author:

    Shashikant D. Barhate*1, Dr. Madhabhai M. Patel2, Amol B. Patil, Sandeep R. Pawar and Sumit R. Rathi.

    Title:Formulation and optimization of controlled released floating tablets of clarithromycin
    Journal:Journal of Pharmacy Research
    Vol(issue):9 (March)
    Year:2015
    Page No: (445-448)
  • Experimental Methods Keywords

    Methodology:Formulation and optimization
    Research Materials:clarithromycin

Keywords

HPMC K100LV HPMC K4M Na-CMC and sodium bicarbonate

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