Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000455
Title: Formulation and evaluation of controlled release alginate microspheres using locust bean gum
Category: Pharmaceutics
Section: Research Article
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    The microspheres were prepared by ionic cross-linking technique. Chemical reaction between sodium alginate and calcium chloride to form calcium alginate was utilized for microspheres. For slowing the rate of release from microspheres the hydrophilic polymer Locust bean gum was used in different concentration with model drug as Diclofenac sodium, so that the drug will be release constantly for 12hrs. The formulation prepared showed the angle of repose within acceptable range having a good flow property. The drug entrapment efficacy of all the formulation was in the range of 90.6–98.9%. The drug entrapment efficacy of microspheres increases with increase in concentration of hydrophilic gums. In vitro drug release from microspheres was studied. The microspheres containing 1.5% of Locust bean gum shows 97.8% drug release. The values of co-efficient correlation (r) were calculated and were found to be linear for first order release as compare to zero order release. Stereo microscopy invade that the microspheres are spherical in shape and with porus surface. Stability studies reveled that polymers used were stable and compatible with the drug and there is no significant effect on physical characteristics, drug content and dissolution profile of the microsphere.

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    Author(s) Name:

    V. N. Deshmukh*, D. M.Sakarkar, R.B. Wakade

    Affiliation(s) Name:

    *Sudhakarrao Naik Institute of Pharmacy, Pusad, Dist- Yavatmal (M.S.), 445204

    For correspondence:V. N. Deshmukh,Department of Pharmaceutics, Sudhakarrao Naik Institute of Pharmacy, Pusad, Dist- Yavatmal (M.S.), 445204, M.H. India.

    Received on:09-09-2008; Accepted on :14-02-2009

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    Author:

    V. N. Deshmukh*, D. M.Sakarkar, R.B. Wakade

    Title:Formulation and evaluation of controlled release alginate microspheres using locust bean gum
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (March)
    Year:2009
    Page No: (458-461)
  • Experimental Methods Keywords

    Methodology:Formulation and evaluation
    Research Materials:Diclofenac sodium

Keywords

Microspheres Diclofenac sodium Locust bean gum Sodium alginate Calcium chloride

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