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Abstract

Oral cancer is one of the most common cancers in the world. It is highly painful and fatal. Since oral cancer is a disease with high mortality, early diagnosis can aid in whole lot of treatment options and opportunities for the patient. Oral cancer which is considered to have a strong relation with chronic inflammation triggers the release of C-reactive protein (CRP) which is usually released in response to inflammation. CRP was discovered by Tillet and Frances, in 1930. CRP was discovered in Oswald Avery’s laboratory during a research on Streptococcus pneumoniae infection. CRP comes under the class “acute-phase proteins.” Acute-phase proteins are plasma proteins which play a very important role in inflammation. They are released into the bloodstream in response to any pathological or physiological changes. CRP is a pentameric non- glycosylated polypeptide. Each component of CRP has 206 amino acid residues. It belongs to the short pentraxin family. Pentraxins have a characteristic structure. It has a cyclic 5-fold symmetric arrangement of protomers. The synthesis of CRP occurs primarily in the hepatocytes of the liver. From various studies on oral cancer, it has been observed that there is an elevation in the serum levels of CRP in oral cancer. These elevated levels significantly differ with different stages and grades of cancer. Therefore, elevated CRP levels which act as a prognostic marker can play a very important role in early diagnosis of oral cancer and thus save lives.

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	JPR Solutions

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