Journal: Drug Invention Today
Title: Preliminary phytochemical screening and cytotoxic activity of Indian medicinal plant against human breast cancer cell line
Category: Pharmacology
Section: Research Article
- Abstract
- Audio Abstract
- Authors
- Pdf File
- Citation
- My Reference
- Methodology
-
Abstract
Objectives: The objectives of the study were to evaluate the cytotoxic activity of Alstonia scholaris (Bark) against human breast cancer cell line Michigan Cancer Foundation-7 (MCF-7) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Materials and Methods: The bark part of A. scholaris was subjected to Soxhlet extraction using hexane, ethyl acetate, ethanol, and aqueous solvents based on their polarity. The crude extracts obtained were subjected to preliminary phytochemical analysis and tested for cytotoxicity activity against human breast cancer cell line (MCF-7) using MTT assay. Results: Phytochemical screening of different extracts, i.e., hexane, ethyl acetate, ethanol, and aqueous extracts of A. scholaris revealed the presence of alkaloids, flavonoids, terpenoids, steroids, cardiac glycosides, etc., as major components. The cytotoxic activity of four different extracts was studied using MCF 7 cell line. The ethanol extract of A. scholaris showed significant cytotoxic effect when compared to other extracts. Conclusion: The results obtained indicated that the ethanol extract of A. scholaris has excellent cytotoxic activity, and further studies will be performed to isolate the novel compounds for chemotherapeutic use.
-
Abstract Audio
No Audio file found
About the authors and Affiliations
Author(s) Name: V. Jayashree, Malarkodi Velraj*
Affiliation(s) Name: Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India
*Corresponding author: Dr. Malarkodi Velraj, Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.-
View Article File in pdf format.
Article File
-
View Article Citation Here.
0 View More -
How to Cite my Article.
Author: V. Jayashree, Malarkodi Velraj*
Title: Preliminary phytochemical screening and cytotoxic activity of Indian medicinal plant against human breast cancer cell line Journal: Drug Invention Today Vol(issue): 11 (December [ Special Issue 2]) Year: 2019 Page No: (246-249) -
Experimental Methods Keywords
Methodology: Cytotoxic activity, Phytochemical screening Research Materials: Alstonia scholaris
Keywords
Our Services
- Citric acid production from cane molasses using submerged fermentation by Aspergillus niger ATCC9142
- Local tissue damage induced by Echis carinatus venom: Neutralization by Albizia lebbeck seed aqueous extract in mice model
- Synthesis, in vitro antifungal and antitubercular evaluation of novel amino pyrimidines based tetrazole derivatives
- Vascular activity of protopanaxadiol and protopanaxatriol, the major saponin fractions isolated from roots of Panax notoginseng
- A review of materials used in maxillofacial prosthesis - Part 1
- Sleep deprivation and cell phone usage among teenagers
- Effect of music on academic performance of college students
- Evaluation of herbal and chemical-based mouthwash against oral pathogensM. Nagalingam1 *, M. Vikramathithan2 , A. Dhanesh Gandhi 3 , S. Rajeshkumar4 *
- Medicinal uses of banana (Musa paradisiaca)
- Effect of aerobics on women among South Indian population
- Effect of proprioception training and backward walking training among diabetic neuropathy patients
- Evaluation of PH and buffering capacity of sports drinks and carbonated drinks
- Evaluation of in vitro antidiabetic potential of lavender oil
- Biosynthesis of silver nanoparticles with Mentha spicata against Aspergillus niger
- The role of If and ICa,L in α-adrenergic regulation of rats cardiac activity
- Phytochemical, pharmacological and phytopharmaceutics aspects of Sesbania grandiflora (Hadga) : A review
- PEPTIC ULCER AND ITS MANAGEMENT
- Antimicrobial activity and phytochemical screening of five wild plants against Escherichia coli, Bacillus subtilis and Staphylococcus aureus
- In-vitro anti-arthritic activity of Abutilon indicum (Linn.) Sweet
- Current Trends in Herbal Medicines
- Multiple-Unit-Pellet System (MUPS): A Novel Approach for Drug Delivery
- Abrus precatorius Linnaeus: A Phytopharmacological Review
- Oral health status, dental awareness, and dental services utilization barriers among transgender population in Chennai
- Biofilm inhibitory activity of plant-derived antioxidant compounds among Staphylococcus epidermidis obtained from clinical samples
- Preliminary phytochemical screening of Eichhornia crassipes: the world’s worst aquatic weed
- A case study on efficacy of soft tissue mobilization and proprioceptive neuromuscular facilitation techniques in subject with shoulder impingement syndrome
- Antidiabetic activity of insulin plant (Costus igneus) leaf extract in diabetic rats
- Prevalence of cervical spondylosis among bike riders in South Indian population – A population-based study
- Development and Validation of Stability Indicating UV Spectrophotometric Method for the Estimation of Sitagliptin Phosphate in Bulk and Tablet Dosage Form
- Extraction of Betacyanin from Red Beet root (Beta vulgaris L.) and to evaluate its antioxidant potential antioxidant potential