Journal: Drug Invention Today
Title: Preliminary phytochemical screening and cytotoxic activity of Indian medicinal plant against human breast cancer cell line
Category: Pharmacology
Section: Research Article
- Abstract
- Audio Abstract
- Authors
- Pdf File
- Citation
- My Reference
- Methodology
-
Abstract
Objectives: The objectives of the study were to evaluate the cytotoxic activity of Alstonia scholaris (Bark) against human breast cancer cell line Michigan Cancer Foundation-7 (MCF-7) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Materials and Methods: The bark part of A. scholaris was subjected to Soxhlet extraction using hexane, ethyl acetate, ethanol, and aqueous solvents based on their polarity. The crude extracts obtained were subjected to preliminary phytochemical analysis and tested for cytotoxicity activity against human breast cancer cell line (MCF-7) using MTT assay. Results: Phytochemical screening of different extracts, i.e., hexane, ethyl acetate, ethanol, and aqueous extracts of A. scholaris revealed the presence of alkaloids, flavonoids, terpenoids, steroids, cardiac glycosides, etc., as major components. The cytotoxic activity of four different extracts was studied using MCF 7 cell line. The ethanol extract of A. scholaris showed significant cytotoxic effect when compared to other extracts. Conclusion: The results obtained indicated that the ethanol extract of A. scholaris has excellent cytotoxic activity, and further studies will be performed to isolate the novel compounds for chemotherapeutic use.
-
Abstract Audio
No Audio file found
About the authors and Affiliations
Author(s) Name: V. Jayashree, Malarkodi Velraj*
Affiliation(s) Name: Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India
*Corresponding author: Dr. Malarkodi Velraj, Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.-
View Article File in pdf format.
Article File
-
View Article Citation Here.
0 View More -
How to Cite my Article.
Author: V. Jayashree, Malarkodi Velraj*
Title: Preliminary phytochemical screening and cytotoxic activity of Indian medicinal plant against human breast cancer cell line Journal: Drug Invention Today Vol(issue): 11 (December [ Special Issue 2]) Year: 2019 Page No: (246-249) -
Experimental Methods Keywords
Methodology: Cytotoxic activity, Phytochemical screening Research Materials: Alstonia scholaris
Keywords
Our Services
- Extraction of Betacyanin from Red Beet root (Beta vulgaris L.) and to evaluate its antioxidant potential antioxidant potential
- Review On: Fast Dissolving Tablet
- Formulation and evaluation of Aloe vera gels
- Modified release dosage form and drug delivery
- Effect of Kapalbhati Pranayama in the blood sugar level in diabetic patients
- Awareness on soil pollution among school students
- In vitro-In vivo Correlation (IVIVC): A Review
- Estimation of Tizanidine HCl by UV-Spectrophotometric Method
- Lemongrass in dental health
- Sodium alginate: the wonder polymer for controlled drug delivery
- A review on cataract and its herbal treatments
- A comparative study of common technical document in different regulated market
- Academic stress and its effect on medical students’ mental health status
- Analysis of Amino Acids By Paper Chromatography
- Chromolaena odorata (L.) : An Overview
- Formulation design and development of Orodispersible tablets of Levetiracetam
- A comparative study on the efficacy of lycopene and quercetin in oral submucous fibrosis cell lines
- Comparitive study on phytochemicals from leaves of Mentha piperita (Mint), Psidium guajava (Guava) and Moringa oleifera (Drumstick)
- Impurity profile- A review
- Plant natural products: Their pharmaceutical potential against disease and drug resistant microbial pathogens
- Effect of stress on academic performance of students in different streams
- In silico study of Rumput Fatimah (Anastatica hierochuntica L.) estrogenic activities and its potential as phytoestrogens
- Impact of poultry consumption by adolescent females – An analytical study
- Cow Urine Concentrate : A potent agent with Antimicrobial and Anthelmintic activity
- Review on Stereospermum suaveolens DC : A Potential Herb
- GC-MS study and phytochemical profiling of Mimosa pudica Linn.
- Standardization of Nandhi Mezhugu, a poly herbomineral Siddha formulation
- Validation of water system: A review
- Awareness of effects of sleep deprivation among college students
- Use of Canna indica Flower Extract As A Natural Indicator In Acid Base Titration