Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004568
Title: Lifestyle and substance use-an important cause for treatment-resistant depression and major depressive disorders
Category: Pharmacology
Section: Review Article
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  • Abstract

    Depression is common mental health disorder or illness across the globe with a high rate of prevalence. The depression is mainly associated with comorbid conditions such as substance abuse and ultimately leads to the treatment-resistant depression (TRD), where the patients develop an inadequate response to the adequate antidepressant therapy and that is the focus of the review. Recent studies confirmed that substance abuse and substance dependence disorders are positively related to lifestyle. This review is discussed about the hypothesis between the lifestyle style pattern, substance use disorders, and TRD. The first half of the review is discussed about the definitions, prevalence, and extent of substance use in different regions. The objective of the review is to provide concise data that, how the health-related lifestyle, extent of substance and its relationship with the TRD and depression. In second half of this review, review emphasized the positive and negative relationships between the unhealthy lifestyle, substance use, and TRD. The unhealthy lifestyle leads exposure to stress environments, which in turn influences many to practice substance use which may act as the risk factor for the depression and long-term untreated depression may relapse into the TRD. In the conclusion of this review, the complications of lifestyle and substance use, their direct impact on the development of depression, and TRD.

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    Author(s) Name:

    B. R. Pramod1 , Seema Mehdi 1 *, Krishna Undela2 , M. Kishor3 , P. Vengal Rao1 , K. L. Krishna1

    Affiliation(s) Name:

    1 Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India,

    2 Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India,

    3 Department of Psychiatry, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, Karnataka India

    *Corresponding author: Seema Mehdi, Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru - 570 015, Karnataka, India

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    Author:

    B. R. Pramod1 , Seema Mehdi 1 *, Krishna Undela2 , M. Kishor3 , P. Vengal Rao1 , K. L. Krishna1

    Title:Lifestyle and substance use-an important cause for treatment-resistant depression and major depressive disorders
    Journal:Drug Invention Today
    Vol(issue):11 (December [ Special Issue 2])
    Year:2019
    Page No: (284-290)
  • Experimental Methods Keywords

    Methodology:treatment-resistant depression and major depressive disorders
    Research Materials:Lifestyle

Keywords

Alcohol dependence Depression Lifestyle Substance use Treatment-resistant depression

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