Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000460
Title: Formulation and evaluation of matrix floating tablet of Famotidine
Category: Pharmaceutics
Section: Research Article
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  • Abstract

    The objective of the present study was to develop single unit gastroretentive drug delivery system of Famotidine. Famotidine is histamine H2 receptor antagonist. It is widely for duodenal ulcers, gastric ulcers, gastro esophageal reflux disease and erosive esophagitis. Famotidine is having a short biological half-life of 2.5-3.5 hrs. The gastroretentive drug delivery system can be retained in the stomach and assist in improving the oral sustained delivery of drugs. The floating matrix drug delivery system of famotidine was prepared by using sodium alginate, HPMC K15M, sodium bicarbonate and citric acid. The formulated formulations showed good buoyancy, in vitro sustained release of famotidine and good stability at short term accelerated stability study.

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    Author(s) Name:

    Sumit R. Rathi*1, Dr. V. R. Patil2, Dr. M. M. Patel3, Amol B. Patil, Gaurav A.Shankhpal and S. D. Barhate.

    Affiliation(s) Name:

    *1Dept. of Pharmaceutics, Smt. S. S. Patil College of Pharmacy, Chopda- 425107. Maharashtra.
    2Principal, College of Pharmacy, Faizpur, Maharashtra.
    3 Principal, Kalol Institute of Pharmacy, Kalol -382721. Gujarat.

    For correspondence:Sumit R. Rathi,Dept. of Pharmaceutics, Smt. S. S. Patil College of Pharmacy, Chopda- 425107. Maharashtra


    Received on:11-09-2008; Accepted on :17-01-2009

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    Author:

    Sumit R. Rathi*1, Dr. V. R. Patil2, Dr. M. M. Patel3, Amol B. Patil, Gaurav A.Shankhpal and S. D. Barhate.

    Title:Formulation and evaluation of matrix floating tablet of Famotidine
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (March)
    Year:2009
    Page No: (531-533)
  • Experimental Methods Keywords

    Methodology:Formulation and evaluation
    Research Materials:Famotidine

Keywords

Formulation evaluation floating tablet ; Famotidine

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