Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-0000461
Title: Isolation of Chemical Constituents from Prosopis juliflora bark and Anti-inflammatory activity of Its Methanolic Extracts
Category: Pharmaceutical Chemistry
Section: Research Article
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  • Abstract

    The methanolic extracts of Prosopis juliflora bark used for the evaluation of anti-inflammatory activity and isolation of constituents. For the evaluation of anti-inflammatory activity carrageenan and histamine induced paw oedema served as acute models and formation granulation tissues by cotton pellets served as a chronic model in rats. The effect was compared with diclofenac sodium, used as standard drug. The methanolic extract of Prosopis juliflora bark (MEPJ) 100, 200 and 400 mg/ kg (p.o.) exhibited significant anti-inflammatory activity in acute and chronic inflammatory models. At the dose level 400 mg/ kg (p.o.) showed maximum inhibition of 55.32% in carrageenan induced rat paw oedema while the standard diclofenac inhibited it by 61.33 % after 3 h of carrageenan injection. All the doses of MEPJ showed dose dependent inhibition against histamine and serotonin induced rat paw oedema as compared with control animals. Furthermore, the same dose levels successfully reduced formation granulation tissues by cotton pellets in rats. Alkaloids, 3’’’’-Oxo-juliprosopine and Secojuliprosopinal were isolated and characterized.

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    Author(s) Name:

    T. SivaKumar a , K. Srinivasan*a, R.Rajavel a ,M.Vasudevan a, M. Ganesh a, K.Kamalakannan a, P.Mallika b

    Affiliation(s) Name:

    *a Nandha College of Pharmacy, Koorapalyam Pirivu, Erode-638 052, Tamil Nadu, India.
    b. National facility for marine cynobacteria,tirchy,Tamil Nadu, India.


    For correspondence:Dr.T.Sivakumar, Principal,Department of Pharmaceutical Chemistry, Nandha College of Pharmacy, Koorapalayam Pirivu, Erode -638 052, Tamilnadu, India.

    Received on:11-12-2008; Accepted on :04-02-2009

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    Author:

    T. SivaKumar a , K. Srinivasan*a, R.Rajavel a ,M.Vasudevan a, M. Ganesh a, K.Kamalakannan a, P.Mallika b

    Title:Isolation of Chemical Constituents from Prosopis juliflora bark and Anti-inflammatory activity of Its Methanolic Extracts
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (March)
    Year:2009
    Page No: (551-556)
  • Experimental Methods Keywords

    Methodology:Isolation of Chemical Constituents, Anti-inflammatory activity
    Research Materials:Prosopis juliflora

Keywords

Prosopis juliflora bark; isolation; anti-inflammatory; carrageenan; cotton pellets induced granuloma

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