Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000462
Title: Preparation and Evaluation of Fluconazole Topical Microemulsion
Category: Pharmaceutics
Section: Research Article
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  • Abstract

    A fluconazole w/o microemulsion was developed for topical application using isopropyl myristate as the oil phase. Pseudoternary phase diagrams were constructed to determine the microemulsion existence region using surfactant (tween 80) and co-surfactant (polyethylene glycol 400). Different formulations were prepared to evaluate the effect of oil content, surfactant/ co-surfactant concentration on in-vitro permeation rates. In-vitro transdermal permeability of fluconazole from the microemulsions was evaluated using Keshary Chien diffusion cells mounted with 0.45μ cellulose acetate membrane. The amount of fluconazole permeated was analyzed by HPLC. The permeability of the fluconazole incorporated into the microemulsion systems was 2.5 - fold higher than that of the marketed formulation. These results indicate that the microemulsion system studied is a promising tool for the percutaneous delivery of fluconazole.

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    Author(s) Name:

    Magdum Chandrakant S., Naikwade Nilofar S., Shah Rohit R.*

    Affiliation(s) Name:

    *Appasaheb Birnale College of Pharmacy, South Shivaji Nagar, Sangli.Maharastra, India

    For correspondence:Shah Rohit R,Department of Pharmaceutics, Appasaheb Birnale College of Pharmacy, South Shivaji Nagar, Sangli.Maharastra, India


    Received on:11-09-2008; Accepted on :04-02-2009

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    Author:

    Magdum Chandrakant S., Naikwade Nilofar S., Shah Rohit R.*

    Title:Preparation and Evaluation of Fluconazole Topical Microemulsion
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (March)
    Year:2009
    Page No: (557-562)
  • Experimental Methods Keywords

    Methodology:Preparation and Evaluation
    Research Materials:Fluconazole

Keywords

Fluconazole Topical Microemulsion permeation

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