Journal: Journal of Pharmacy Research

Article Id: JPRS-ND-0000463
Title: Effect of various Ayurvedic formulations and medicinal plants on carbohydrate hydrolyzing enzymes and glucose uptake by yeast cells-an in vitro study
Category: Natural Drugs
Section: Research Article
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    The present study evaluated the effect of three Ayurvedic formulations and five medicinal plants commonly used in the treatment of diabetes on α-amylase, α-glucosidase, sucrase and glucose uptake by yeast cells in vitro. All the Ayurvedic formulations inhibited the enzymes to varying degrees. Although all the medicinal plants studied inhibited a-amylase to an extent of 16-74%, only Eugenia jambulana and Ficus racemosa inhibited all the three enzymes while, Tinospora cardifolia and Gymnema sylvestrae activated α-glucosidase and sucrase. Aegle marmelos inhibited sucrase but increased the activity of α-glucosidase. All the samples except Aegle marmelos significantly increased (p=0.01) glucose uptake in yeast cells. The enhancement of glucose uptake was dependent on both the sample and glucose concentration. It is proposed that, the mechanism of hypoglycemic action varies greatly from one medicinal plant to other and hence, there is a need for in depth research to establish the mode of action of each medicinal plant for their effective utilization as therapeutic agents.

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    Author(s) Name:

    Faiyaz Ahmed*, Sudha Sairam and Asna Urooj

    Affiliation(s) Name:

    *Department of Studies in Food Science and Nutrition, University of Mysore, Mysore, India.


    For correspondence:Dr. Faiyaz Ahmed, Department of Studies in Food Science and Nutrition, University of Mysore, Mysore, India. 


    Received on:12-09-2008; Accepted on :04-01-2009

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    Author:

    Faiyaz Ahmed*, Sudha Sairam and Asna Urooj

    Title:Effect of various Ayurvedic formulations and medicinal plants on carbohydrate hydrolyzing enzymes and glucose uptake by yeast cells-an in vitro study
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (March)
    Year:2009
    Page No: (563-568)
  • Experimental Methods Keywords

    Methodology:alpha-glucosidase, glucose uptake, sucrase, diabetes
    Research Materials:Medicinal plants

Keywords

Medicinal plants alpha-amylase alpha-glucosidase glucose uptake sucrase diabetes

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