Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-0000466
Title: Hypolipidemic effect of Methanolic extract of Mussaenda frondosa linn. Leaves in high fat diet fed rats
Category: Pharmacology
Section: Research Article
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    High fat diet fed rats showed significant Increased levels of plasma and total cholesterol, triglycerides, free fatty acids, phospholipids plasma LDL cholesterol and decreased level of plasma HDL cholesterol. Methanolic extract of M.frondosa administration to high fat diet fed rats showed near normal levels of the above lipids in plasma and tissues. When higher dose of the extract (400-450 mg/kg body weight) showed prominent results with the standard drug atorvastatin (1.2mg/kg). Results obtained from this study suggest that the hypolipidemic effect of Methanolic extract of Mussaenda frondosa may be due to the inhibition of hepatic cholesterogenesis and may have slight antioxidant activity. It is therefore concluded that the methanolic extract of M.frondosa possesses hypolipidemic activity in high fat diet fed rats.

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    Author(s) Name:

    *¹J. John wesley, J. Jeyaananathi, A. Mohammed Ansar, ² K. Ravikumar

    Affiliation(s) Name:

    *¹ Dept. of Pharmacology, Arulmigu Kalasalingam college of Pharmacy, Anand Nagar, Krishnakoil – 626 190.
    ² Dept. Of Pharmacology, K.M. College of Pharmacy, Uthangudi, Madurai – 625 107


    For correspondence: J. John Wesley,Dept. of Pharmacology, Arulmigu Kalasalingam college of Pharmacy, Anand Nagar, Krishnakoil – 626 190.


    Received on:11-12-2008; Accepted on :04-02-2009

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    Author:

    *¹J. John wesley, J. Jeyaananathi, A. Mohammed Ansar, ² K. Ravikumar

    Title:Hypolipidemic effect of Methanolic extract of Mussaenda frondosa linn. Leaves in high fat diet fed rats
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (April)
    Year:2009
    Page No: (579-581)
  • Experimental Methods Keywords

    Methodology: Hypolipidemic effect
    Research Materials:Mussaenda frondosa

Keywords

Mussaenda frondosa Hypolipidemic effect Rubiaceae Mussaein.

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