Journal: Journal of Pharmacy Research

Article Id: JPRS-MB-0000468
Title: Production of prodigiosin from Serratia marcescens and its Cytotoxicity activity
Category: Microbiology
Section: Research Article
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    The Cytotoxicity activity of prodigiosin from Serratia marcescens (MTCC 97*) were tested under in vitro conditions against cancer cell line. The anticancer activity of prodigiosin against HeLa cell was also showed satisfying results. The test was carried at different concentration 0, 10, 20, 30, 40μg/ml and the percentage of cell viability was recorded at 24, 48, 72 and 96 hours. The percentage of cell death was 54% after 96 hours. The IC50 value was 35μg/ml for 48 hours. This paper communicates cytotoxicity activity of prodigiosin. However further research are required to study the mechanism of cancer cell line inhibition.

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    Author(s) Name:

    Davaraj Naveen Raj, Dharumaduari Dhanasekaran* ,Noorudin Thajuddin and Annamalai Panneerselvam1

    Affiliation(s) Name:

    *Department of Microbiology, School of Life Sciences, Bharathidasan University, Tiruchirappalli, 620 024.
    1 P.G. & Research Department of Botany & Microbiology, A.V.V.M. Sri Pushpam College, (Autonomous), Poondi, 613 503 Thanjavur District, Tamil Nadu. India


    For correspondence:Dr.D.Dhanasekaran,Department of Microbiology,School of Life Sciences,Bharathidasan University,Tiruchirappalli- 620024 ,TamilNadu,India

    Received on:16-12-2008; Accepted on 24-02-2009

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    Author:

    Davaraj Naveen Raj, Dharumaduari Dhanasekaran* ,Noorudin Thajuddin and Annamalai Panneerselvam1

    Title:Production of prodigiosin from Serratia marcescens and its Cytotoxicity activity
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (April)
    Year:2009
    Page No: (590-593)
  • Experimental Methods Keywords

    Methodology:cytotoxicity activity, cancer cell line
    Research Materials:Serratia marcescens

Keywords

Prodigiosin Serratia marcescens cytotoxicity activity cancer cell line

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