Journal: Drug Invention Today

Article Id: JPRS-MSNS-00004691
Title: The synergistic effect for sesame oil-ciprofloxacin on the sensitivity of some Enterobacteriaceae species
Category: Microbiological Study (on Natural/ Synthetic drug)
Section: Research Article
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    Background: Hospital-acquired infections are important problems in developing countries with high prevalence rate. Enterobacteriaceae members regarded the most important pathogens among those responsible for such infections. Due to the high prevalence of antibiotic-resistant strains in pathogenic microorganisms that have emerged in recent decades, extensive studies have been conducted on the use of natural products and biologically active compounds extracted from medicinal plants. Methodology: This study was designed to determine the effect of sesame oil on increasing the sensitivity of ciprofloxacin (CIP) resistant bacteria where oil works synergistically with antibiotic as a bacteriostatic or bactericidal. Results: Thirty-two samples of people with urinary tract infections and diarrhea were isolated at Al-Ramadi Teaching Hospital and Private Laboratories, the different bacterial species isolated belong to Enterobacteriaceae included Escherichia coli, Klebsiella, Proteus, Pseudomonas, and Salmonella. The results showed the isolates converted from CIP resistance to sensitive when mix the sesame oil with CIP and the sensitivity increased with increased the concentration of sesame oil in E. coli (8–30 mm), Klebsiella (10–26 mm), Proteus (8–22 mm), and Salmonella (10–24 mm), respectively. Conclusion: The results of this study showed that there is an important effect of sesame oil synergistically with CIP on the Enterobacteriaceae resistant to this antibiotic and causing urinary tract infection and diarrhea and did not show the same effect when adding sesame oil or antibiotics separately.

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    Author(s) Name:

    Amna B. Malhan1 , Laith M. Najeeb2 , Harith K. Buniya1 *

    Affiliation(s) Name:

    1Department of Biology, College of Education for Pure Science, University of Anbar, Anbar,  Iraq,

    2 Department of Biology, College of Sciences, University of Anbar, Anbar, Iraq

    *Corresponding author: Harith K. Buniya, Department of Biology, College of Education for Pure Science, University of Anbar, Anbar, Iraq.

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    Author:

    Amna B. Malhan1 , Laith M. Najeeb2 , Harith K. Buniya1 *

    Title:The synergistic effect for sesame oil-ciprofloxacin on the sensitivity of some Enterobacteriaceae species
    Journal:Drug Invention Today
    Vol(issue):11 (December )
    Year:2019
    Page No: (3309-3312)
  • Experimental Methods Keywords

    Methodology:synergistic effect, sensitivity
    Research Materials:Sesame oil

Keywords

Ciprofloxacin Proteus spp. Salmonella spp. Sesame oil

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