Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-0000471
Title: Protective Effect of Polyherbal Formulation on Isoniazid Induced Hepatotoxicity in Rats
Category: Pharmacology
Section: Research Article
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    Objective: To evaluate effect of Polyherbal Formulation (PHF) on isoniazid induced hepatotoxicity in rats and assessment of any possibility of co administration of PHF along with such hepatotoxic drug.Materials and Methods: Hepatotoxicity in rat was induced by Isoniazid (INH) (200mg/kg/p.o. for 24 days) and protective effect of PHF (0.25ml/kg/p.o. and 0.5ml/kg/p.o. either along with hepatotoxic drugs or followed by inducing hepatotoxicity) was measured by estimating marker enzymes for liver function like Aspartate aminotransferase, Alanine aminotransferase, Alkaline phosphatase and g glutamic transpeptidase. Oxidative stress markers like lipid peroxidation, reduced glutathione, super oxide dismutase and catalase. Protein profile likes Total bilirubin, direct bilirubin, Total albumin and Total protein. Histopathological study was carried out to confirm hepatotoxicity. Results and Discussions: Isoniazid induced hepatotoxicity characterized by significant increase in marker enzymes for liver function and oxidative stress along with depletion of proteins. Administration of PHF either along with Isoniazid or followed by inducing hepatotoxicity significantly improved the level of marker enzymes for liver function, oxidative stress and depleted proteins profile. Conclusion: The study suggest protective role of PHF and it can be utilized to treat the hepatotoxicity with long-term clinically useful drugs, which are at the risk of developing hepatotoxicity.

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    Author(s) Name:

    Jitendra Vaghasiya1*, Yagnik Bhalodia1, Malaviya Shailesh1, Nurudin Jivani1, Shivkumar Rathod 2

    Affiliation(s) Name:

    *1Department of Pharmacology,Smt. R.B.Patel Mahila Pharmacy College, S.N.D.T Women’s University, Atkot, Gujarat, India.
    2Department of Pharmacology,M. S. University of Baroda, Vadodara, Gujarat, India.


    For correspondence:Jitendra Vaghasiya,Department of Pharmacology, Smt. R. B. Patel Mahila pharmacy College, Atkot, Gujarat, India.


    Received on:11-12-2008; Accepted on :04-02-2009

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    Author:

    Jitendra Vaghasiya1*, Yagnik Bhalodia1, Malaviya Shailesh1, Nurudin Jivani1, Shivkumar Rathod 2

    Title:Protective Effect of Polyherbal Formulation on Isoniazid Induced Hepatotoxicity in Rats
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (April)
    Year:2009
    Page No: (610-614)
  • Experimental Methods Keywords

    Methodology:Hepatotoxicity;Oxidative stress; Protein profile.
    Research Materials:Polyherbal Formulation

Keywords

Hepatotoxicity; Isoniazid; Polyherbal Formulation; Oxidative stress; Protein profile.

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