Journal: Journal of Pharmacy Research

Article Id: JPRS-PHDRS-0000476
Title: Hepatoprotective effect of Azadirachta indica (Neem) leaves against alcohol induced liver injury in albino rats
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
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    Herbal drugs are traditional used in various parts of the world to cure different diseases. The Ayurvedic and Siddha medical systems are very famous medical practices in Indian traditional medicines. The purpose of this study was to evaluate the hepatoprotective activity of A . indica using a ethyl alcohol induced liver injury in rats and probe into its mechanism of action. Liver damage was induced in Wistar rats (150-200g) by administrating 30% ethyl alcohol (1ml/100g b.wt.) once daily for 14 days. A. indica (1g/kg b. wt.) was given for 14 days. Silymarin (0.1g/ kg b. wt.) was given as a reference drug once daily for 14 days. Levels of serum marker enzymes (AST, ALT and ALP) were significantly (p<0.05) increased in ethyl alcohol treated rats. Simultaneously, A. indica leaf powder and silymarin, standard drug significantly (p<0.05) suppressed mainly the increase in plasma activities of AST, ALT and ALP concentration, which are considered as markers of liver functional state. The significant (p<0.05) decrease in the liver total protein (TP) and albumin (Alb) levels after ethyl alcohol treatment, which were reversed with A. indica. These effects were comparable to silymarin. In order to probe the possible mechanism by which A. indica prevents hepatic damage caused by ethyl alcohol, investigation on levels of thiobarbituric acid reactive substance (TBARS) was found to be elevated and significant (p<0.05) decrease in glutathione reductase (GSH), superoxide dismutase (SOD) and catalase (CAT) content of liver after treatment with ethyl alcohol, which were significantly (p<0.05) reversed by A. indica. The effects of A. indica were comparable to that of silymarin. The results of this study confirmed the hepatoprotective activity effect of the A. indica leaf powder.

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    Author(s) Name:

    V. Maruthappan*1, K. Sakthi Shree2

    Affiliation(s) Name:

    *1Unit of Endocrinology, Department of Zoology, Bharathiar University, Coimbatore – 641 046, India.
    2Department of Zoology, Govt. Arts College (Autonomous), Coimbatore – 641 018,India.


    For correspondence:V. Maruthappan, Unit of Endocrinology, Department of Zoology, Bharathiar University, Coimbatore – 641 046, India.

    Received on:13-12-2008; Accepted on :24-02-2009

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    Author:

    V. Maruthappan*1, K. Sakthi Shree2

    Title:Hepatoprotective effect of Azadirachta indica (Neem) leaves against alcohol induced liver injury in albino rats
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (April)
    Year:2009
    Page No: (655-659)
  • Experimental Methods Keywords

    Methodology:Hepatoprotective activity
    Research Materials:A. indica

Keywords

Herbal drugs A. indica Ethyl alcohol Liver injury and Albino rats.

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