Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000478
Title: A validated UV spectrophotometric method for the simultaneous estimation of Lamivudine, Nevirapine and zidovudine in combined tablet dosage form
Category: Pharmaceutics
Section: Research Article
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  • Abstract

    A simple, accurate, precise, economical and reproducible UV spectrophotometric method is being developed for the simultaneous estimation of lamivudine, nevirapine and zidovudine in pure bulk drug and in tablet dosage form. The stock solutions were prepared in 0.5M HCl followed by the further required dilutions with distilled water. The lmax for lamivudine, nevirapine and zidovudine were 280.2nm, 312nm and 266.8nm respectively. Linearity in concentration range of 5-25 mg/ mL, 5-50mg/ mL and 5-40mg/mL was shown respectively by the three drugs. The proposed method has estimated lamivudine 97.56%, nevirapine 98.03% and zidovudine 98.2% in marketed tablets. The results of analysis have been validated statistically and also by recovery studies. Thus the present study gives an excellent method for the determination of all the three drugs in combined dosage formulation without their prior separation.

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  • About the authors and Affiliations

    Author(s) Name:

    Vaishali P. Nagulwar * and Dr. Kishor P. Bhusari

    Affiliation(s) Name:

    *Department of Pharmaceutics,Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur-441 110, INDIA


    *For correspondence:Vaishali P. Nagulwar

    Received on:09-12-2008; Accepted on :12-02-2009

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    Author:

    Vaishali P. Nagulwar * and Dr. Kishor P. Bhusari

    Title:A validated UV spectrophotometric method for the simultaneous estimation of Lamivudine, Nevirapine and zidovudine in combined tablet dosage form
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (April)
    Year:2009
    Page No: (666-669)
  • Experimental Methods Keywords

    Methodology:simultaneous equation method.
    Research Materials:Lamivudine (LAM), Nevirapine (NEV), Zidovudine (ZID)

Keywords

Lamivudine (LAM) Nevirapine (NEV) Zidovudine (ZID) simultaneous equation method.

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