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Abstract

The technique of liquisolid preparation is used to formulate drug solution in solid dosage forms. Drug solution is generally, prepared by dissolving the drug in non-volatile water-miscible solvent. The prepared tablet of liquisolid formulation contains the drug held in solution. Accordingly, the dissolution step, a pre-requiste for drug absorption, may be bypassed and better bioavailability of poorly soluble drugs achieved. Liquisolid system refers to formulations formed by conversion of liquid drugs, drug suspensions or drug solution in non-volatile solvents into dry, nonadherent, free-flowing and compressible powder mixtures by blending the suspension or solution with selected carriers and coating materials. In this technique the drug might be in a solid dosage form, which is held within the powder substrate in solution, or in a solubilized, almost molecularly dispersed state. Therefore, due to their significantly increased wetting properties and surface of drug available for dissolution. Liquisolid compacts of water-insoluble substances may be expected to display enhanced drug release properties and consequently improved bioavailability. Liquisolid technique is a new and promising method that can change the dissolution rate of drugs. It is claimed that if hydrophobic carriers such as Eudragit RL and RS are used instead of hydrophilic carries in liquisolid systems, sustained release systems can be obtained.

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	JPR Solutions

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