Journal: Drug Invention Today

Article Id: JPRS-MSNS-00004854
Title: Study of nasal carriers of ESKAPE pathogens among healthcare workers from intensive care unit
Category: Microbiological Study (on Natural/ Synthetic drug)
Section: Research Article
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    Introduction: Over the past few decades, antimicrobial resistance is one of the most important health concerns. Along with the problem of nosocomial infections, the presence of multidrug-resistant bacteria in communities and hospitals has been increased. High frequencies of multidrug-resistant bacteria have been grouped under the acronym ESKAPE: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. The ESKAPE pathogens are responsible for the majority of nosocomial infections and capable of “escaping” the biocidal action of antimicrobial agents.Materials and Methods: This is a cross-sectional study, which was carried out in 2 months in the Department of Microbiology, in Sri Lakshmi Narayana Institute of Medical Science, Pondicherry. Nasal swabs were collected from health workers from intensive care unit (ICU). Then, these swabs were sent to the laboratory for culture and antibiotic susceptibility tests. Antimicrobial susceptibility testing was done on Mueller-Hinton agar. Results: A total of 50 healthcare workers who work in different parts of the hospital were studied. Of 50 healthcare workers, 35 (70%) were female and 15 (30%) were male. Healthcare workers carry K. pneumoniae 6 (12%), S. aureus 8 (16%), 3 (6%) K. pneumoniae, and S. aureus 5 (10%). Conclusion: If we understand how the ICU workers act as a carrier of pathogens, we can implement new methods for preventing it. Treatment of nosocomial infections can be challenging due to the high level of antibiotic resistance of nosocomial pathogens and the frequent immune suppression of the host. We will use this knowledge gathered on both microbial factors and host responses to develop novel therapeutic strategies to prevent or fight nosocomial infections.

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    Author(s) Name:

    S. Jayapradha, Vindhuja Vijay, G. Jayalakshmi*, V. Abarna, C. Naveenkumar, Swathi

    Affiliation(s) Name:

    Department of Microbiology, Sri Lakshmi Narayana Institute of Medical Sciences, Pondicherry, India (Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India)

    *Corresponding author: Dr. G. Jayalakshmi, Department of Microbiology, Sri Lakshmi Narayana Institute of Medical Sciences, Pondicherry, India (Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India).

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    Author:

    S. Jayapradha, Vindhuja Vijay, G. Jayalakshmi*, V. Abarna, C. Naveenkumar, Swathi

    Title:Study of nasal carriers of ESKAPE pathogens among healthcare workers from intensive care unit
    Journal:Drug Invention Today
    Vol(issue):11 (December )
    Year:2019
    Page No: (3368-3370)
  • Experimental Methods Keywords

    Methodology: a cross-sectional study
    Research Materials:nasal carriers of ESKAPE pathogens, healthcare workers

Keywords

Enterococcus faecium Staphylococcus aureus Klebsiella pneumoniae Acinetobacter baumannii Pseudomonas aeruginosa and Enterobacter spp.  Intensive care unit Multidrug resistant

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