Journal: Journal of Pharmacy Research
Title: Review On: Fast Dissolving Tablet
Category: Pharmaceutics
Section: Review Article
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Abstract
Tablet is the most popular among all dosage forms existing today because of its convenience of self administration, compactness and easy manufacturing; however hand tremors, dysphasia in case of geriatric patients, the underdeveloped muscular and nervous systems in young individuals and h case of uncooperative patients, the problem of swallowing is common phenomenon which leads to poor patient compliance1.To overcome these drawbacks, mouth dissolving tablets (MDT) or orally disintegrating tablets; (ODT) has emerged as alternative oral dosage forms. These are novel types; of tablets that disintegrate/dissolve/ disperse in saliva within few seconds’. According to European Pharmacopoeia, the ODT should disperse/disintegrate in less than three minutes. The basic approach used in development of MDT is the use of superdisintegrants like Cross linked carboxymelhylcellulose (Croscarmeliose), Sodium starch glycolate (Primogel, Explotab). Polyvinylpyrrolidone (Polyplasdone) etc. which provide instantaneous disintegration of tablet after putting on tongue, thereby releasing the drug in saliva. The bioavailability of some drugs may be increased due to absorption of drugs in oral cavity and also due to pregastric absorption of saliva containing dispersed drugs that pass down into the stomach. Moreover, the amount of drug that is subject to first pass metabolism is reduced as compared to standard tablets. 1-3
Cite this article as: Review On:Fast Dissolving Tablet ,Mukesh P. Ratnaparkhi; Dr.G.P.Mohanta; Dr. Lokesh Upadhyay, ,Journal of Pharmacy Research,Vol.2.Issue 1. January 2009,5-12.
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About the authors and Affiliations
Author(s) Name: *Mukesh P. Ratnaparkhi1; Dr.G.P.Mohanta2; Dr. Lokesh Upadhyay3
Affiliation(s) Name: 1Marathwada Mitra Mandal’s College of Pharmacy, Thergaon (Kalewadi), Pune-411033, India
2Annamalai University Annamalainagar, Annamalai-608002 ,India
3CARISM, Sastra University, Tanjavur-613402, India-
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Author: *Mukesh P. Ratnaparkhi1; Dr.G.P.Mohanta2; Dr. Lokesh Upadhyay3
Title: Review On: Fast Dissolving Tablet Journal: Journal of Pharmacy Research Vol(issue): 2 (January ) Year: 2009 Page No: (5-12) -
Experimental Methods Keywords
Methodology: Drug Delivery System Research Materials: Tablet
Keywords
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