Article Id:JPRS-PCS-000049 Title:Review On: Fast Dissolving Tablet Category:Pharmaceutics Section:Review Article
Abstract
Audio Abstract
Authors
Pdf File
Citation
My Reference
Methodology
Abstract
Tablet is the most popular among all dosage forms existing today because of its convenience of self administration, compactness and easy manufacturing; however hand tremors, dysphasia in case of geriatric patients, the underdeveloped muscular and nervous systems in young individuals and h case of uncooperative patients, the problem of swallowing is common phenomenon which leads to poor patient compliance1.To overcome these drawbacks, mouth dissolving tablets (MDT) or orally disintegrating tablets; (ODT) has emerged as alternative oral dosage forms. These are novel types; of tablets that disintegrate/dissolve/ disperse in saliva within few seconds’. According to European Pharmacopoeia, the ODT should disperse/disintegrate in less than three minutes. The basic approach used in development of MDT is the use of superdisintegrants like Cross linked carboxymelhylcellulose (Croscarmeliose), Sodium starch glycolate (Primogel, Explotab). Polyvinylpyrrolidone (Polyplasdone) etc. which provide instantaneous disintegration of tablet after putting on tongue, thereby releasing the drug in saliva. The bioavailability of some drugs may be increased due to absorption of drugs in oral cavity and also due to pregastric absorption of saliva containing dispersed drugs that pass down into the stomach. Moreover, the amount of drug that is subject to first pass metabolism is reduced as compared to standard tablets. 1-3
Cite this article as: Review On:Fast Dissolving Tablet ,Mukesh P. Ratnaparkhi; Dr.G.P.Mohanta; Dr. Lokesh Upadhyay, ,Journal of Pharmacy Research,Vol.2.Issue 1. January 2009,5-12.
*Mukesh P. Ratnaparkhi1; Dr.G.P.Mohanta2; Dr. Lokesh Upadhyay3
Affiliation(s) Name:
1Marathwada Mitra Mandal’s College of Pharmacy, Thergaon (Kalewadi), Pune-411033, India 2Annamalai University Annamalainagar, Annamalai-608002 ,India 3CARISM, Sastra University, Tanjavur-613402, India