Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000494
Title: Studies on solid dispersion of Felodipine
Category: Pharmaceutics
Section: Research Article
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    Literature reveals the utility of solid dispersions in improving the solubility of poorly water soluble drugs. Felodipine, a calcium channel blocking agent widely used to treat hypertension. Although felodipine is rapidly absorbed after oral administration, it is critical to improve the dissolution rate to enhance the bioavailability, due to its low water solubility. Solid dispersions of felodipine with polyvinylpyrrolidone (PVP K30) and HPMC K4M were prepared by using solvent evaporation method. The prepared solid dispersions were free flowing and showed good percentage of drug content (87%w/w). The FTIR study reveals no chemical interaction between felodipine and carriers used. The XRPD and DSC studies confirm transformation of crystalline form of felodipine into the amorphous form. The in vitro dissolution studies of formulated solid dispersions and tablets of solid dispersions showed that the solid dispersion of felodipine:PVP K30 with the ratio 1:3 enhances the solubility of felodipine.

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    Author(s) Name:

    Sandeep Pawar*1, Dr. Madhabhai M. Patel2, Amol Patil, Sumit Rathi, Rahul Deshmukh and S. D. Barhate

    Affiliation(s) Name:

    *1Department of Pharmaceutics, Smt. S. S. Patil College of Pharmacy, Chopda- 425107. Maharashtra.
    2 Principal, Kalol Institute of Pharmacy, Kalol -382721. Gujarat.


    For correspondence:Sandeep Pawar ,Department of Pharmaceutics, Smt. S. S. Patil College of Pharmacy, Chopda- 425107.

    Received on:24-12-2008; Accepted on :04-02-2009

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    Author:

    Sandeep Pawar*1, Dr. Madhabhai M. Patel2, Amol Patil, Sumit Rathi, Rahul Deshmukh and S. D. Barhate

    Title:Studies on solid dispersion of Felodipine
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (April)
    Year:2009
    Page No: (768-774)
  • Experimental Methods Keywords

    Methodology:Studies on solid dispersion
    Research Materials:Felodipine

Keywords

Solid dispersion Felodipine

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