Journal: Drug Invention Today

Article Id: JPRS-P'Col-00004952
Title: Gingerol effects on 1-methyl-4 phenyl pyridinium-induced Parkinson’s disease cellular model oxidative stress through mitochondrial membrane dysfunction
Category: Pharmacology
Section: Research Article
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    Background of Study: 1-methyl-4 phenyl-pyridinium (MPTP), a neurotoxin inhibits mitochondrial membrane complex mechanism, causes Parkinson’s diseases. MPTP has the ability to generate more debris, neuronal death. The main aim of the study to determine the neuroprotective effects of gingerols against MPTP (neurotoxin) result s cell death (programmed) SK- N-SH cells. Gingerol is an active compound of ginger, which possesses a wide range of pharmacological properties, including potent antioxidant anti-inflammatory and anti-apoptotic. Materials and Methods: Analyzing the following parameters such as MTT assay for cell death and cell viability, mitochondrial membrane potential (ATP), increased/decreased level of reactive oxygen species (ROS) generation, TBRAS levels, and biochemical activities were estimated. The gingerol was treated with (neuroblastoma) cell line to know the loss of mitochondrial membrane potential, increased ROS generations, and other cellular reaction. Results: Data revealed that gingerol has the neuroprotective effect against MPTP due to its antioxidant properties, level of mitochondria function was maintained, anti-inflammatory, and antiapoptotic properties in the cell line also studied.

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    Author(s) Name:

    R. Yasodai 1*,3 , M. Kavimani 2

    Affiliation(s) Name:

    1 Department of Anatomy, Bharat University, Chennai, Tamil Nadu, India,

    2 Department of Anatomy, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India,

    3 Department of Anatomy, Sri Ramakrishna Dental College and Hospital, Coimbatore, Tamil Nadu, India

    *Corresponding author: R. Yasodai, Department of Anatomy, Bharat University, Chennai, Tamil Nadu, India.

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    Author:

    R. Yasodai 1*,3 , M. Kavimani 2

    Title:Gingerol effects on 1-methyl-4 phenyl pyridinium-induced Parkinson’s disease cellular model oxidative stress through mitochondrial membrane dysfunction
    Journal:Drug Invention Today
    Vol(issue):13 (April )
    Year:2020
    Page No: (545-548)
  • Experimental Methods Keywords

    Methodology: MTT assay
    Research Materials: Gingerol

Keywords

Gingerol 1-Methyl-4 phenyl-pyridinium MTT assay Rhodamine 123

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