Journal: Journal of Pharmacy Research

Article Id: JPRS-PHDRS-0000501
Title: In vitro antioxidant and anticholinesterase activity of Acorus calamus and Nardostachys jatamansi rhizomes
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
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    The present study evaluated the free radical scavenging and anticholinesterase activity of the methanolic extracts of Acorus calamus (ACME) and Nardostachys jatamansi (NJME) rhizomes in vitro. In addition, total phenolics (TP) were also estimated. NJME contained significantly higher (p =0.05) phenolics (37 μg GAE/mg) than ACME (23μg GAE/mg). Consequently, NJME exhibited significantly higher (p =0.05) radical scavenging activity than ACME and BHT, a synthetic antioxidant. Further, the IC50 values were 704, 237 & 335 μg/ml for ACME, NJME and BHT respectively. In case of anticholinesterase activity also NJME exhibited significantly higher (p =0.05) activity with lower IC50 value than ACME. However, the anticholinesterase activity of both ACME and NJME were significantly lower (p =0.05) than neostigmine, a standard drug wherein, neostigmine exhibited significantly lower (p =0.05) IC50 value than ACME and NJME. Furthermore, a significant correlation between the total phenolic content, antioxidant and anticholinesterase activities of both the extracts indicating that total phenolics might be responsible for the observed antioxidant and anticholinesterase activities.This is the first report in this direction.

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    Author(s) Name:

    Faiyaz Ahmeda*, Narendra Sharath Chandra J.Nb, Asna Urooja and Rangappa K.Sb

    Affiliation(s) Name:

    aDepartment of Studies in Food Science and Nutrition, University of Mysore, Mysore-570006, India.
    bDepartment of Studies in Chemistry, University of Mysore, Mysore-570006, India.


    Received on: 22-09-2008; Accepted on: 04-01-2009

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    Author:

    Faiyaz Ahmeda*, Narendra Sharath Chandra J.Nb, Asna Urooja and Rangappa K.Sb

    Title:In vitro antioxidant and anticholinesterase activity of Acorus calamus and Nardostachys jatamansi rhizomes
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (May)
    Year:2009
    Page No: (830-833)
  • Experimental Methods Keywords

    Methodology:In vitro antioxidant , anticholinesterase activity
    Research Materials:Acorus calamus , Nardostachys jatamansi rhizomes

Keywords

Acteylcholinesterase antioxidant Acorus calamus jatamansi phenolics.

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