Journal: Drug Invention Today

Article Id: JPRS-P'ceu-00005025
Title: Screening of antibacterial activity of nonsteroidal anti-inflammatory drugs against selected pathogens
Category: Pharmaceutics
Section: Review Article
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    Aim: Screening of antibacterial activity of non-antibiotics – non-steroidal anti-inflammatory drugs (NSAIDS) against selected pathogens such as Bacillus subtilis, Escherichia coli , Pseudomonas aeruginosa and staphylococcus aureus. Materials and Methods: The four NSAIDs were selected based on their common usage, they were aspirin, diclofenac sodium, ibuprofen, and paracetamol. Minimum inhibitory concentration was determined by liquid broth dilution method. Further, their susceptibility was determined by agar disk diffusion method and ofloxacin used as control. Results and Discussion: Among the studied drugs, mostly diclofenac sodium and ibuprofen produced a significant effect and other drugs also produced a milder effect which is not sufficient to inhibit microbial growth when compared to control. Conclusion: The antibacterial effect of non- antibiotics diclofenac sodium and ibuprofen was microorganism dependent. Hence, in microorganism, identified infection can use this drug as antibacterial agents to minimize the effects of overdose and also reduce the usage of antibiotics.

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    Author(s) Name:

    R. Senthilraj 1 *, V. Swetha2 , S. Kavitha1 , A. Haripriya1 , M. Tharunkumar1 , A. Santhosh1

    Affiliation(s) Name:

    1 Department of Pharmaceutics, Faculty of Pharmacy, Dr. M.G.R Educational and Research Institute, Chennai, Tamil Nadu, India,

    2 Department of Pharmaceutics, Karpagam College of Pharmacy, Coimbatore, Tamil Nadu, India

    *Corresponding author: R. Senthilraj, Department of Pharmaceutics, Faculty of Pharmacy, Dr. M.G.R Educational and Research Institute, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    R. Senthilraj 1 *, V. Swetha2 , S. Kavitha1 , A. Haripriya1 , M. Tharunkumar1 , A. Santhosh1

    Title:Screening of antibacterial activity of nonsteroidal anti-inflammatory drugs against selected pathogens
    Journal:Drug Invention Today
    Vol(issue):14 (May)
    Year:2020
    Page No: (692-696)
  • Experimental Methods Keywords

    Methodology:Antimicrobial activity, Non-Antibiotic activity, Nonsteroidal anti-inflammatory
    Research Materials: aspirin, diclofenac sodium, ibuprofen, and paracetamol

Keywords

Antimicrobial activity Non-Antibiotic activity Nonsteroidal anti-inflammatory drugs Side effect antibiotics

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