Journal: Drug Invention Today

Article Id: JPRS-P'Col-00005030
Title: Study of some Crataegus leaves component and effect of their aqueous extract on oxidative stress during ischemia/ reperfusion brain damage
Category: Pharmacology
Section: Research Article
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    Background: Ischemia brain is the main cause of morbidity and mortality in the world. It has been reported that the ischemia brain is a prime reason for a long term of disability in adults. Several studies have been proposed to define the physiological disorders that result in ischemia brain where free radical formation is substantial interest. The free radicals can be formed during cerebral ischemia/reperfusion (I/R) producing free radicals, which have a pivotal role in brain damage. This study focused on the assessing whether and how hawthorn extracts can mitigate cerebral ischemia-reperfusion brain damage in rat model. Materials and Methods: Thirty-six rats were subjected to ischemia for 45 min and then the infected rats were exposed to reperfusion for 60 min. All animals were categorized into three groups: Group 1 (control), Group 2 (I/R), and Group 3 (Crataegus pre-treatment group). Only 0.9% of saline solution was infused internally into rats in Group 2, whereas in Group 3, rats were given Crataegus (200 mg/kg) intraperitoneally for 15 days with the same diet before ischemia and before reperfusion. The biochemical parameters were estimated in serum including oxidative stress levels of lipid peroxidation (LPO) and nitric oxide (NO) while enzyme immunoassay was used to assess interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α), and IL-1 β in blood. Results: The results revealed that the levels of NO and LPO were considerably increased in mice within I/R group (26.93 ± 1.1 and 1.42 ± 0.02, respectively) contrary to the other two groups. It is, however, clear that the concentrations of NO and LPO decreased in the rats pretreated with Crataegus (Group 3) (21.32 ± 0.9 and 0.91 ± 0.08, respectively) compared to I/R group. In terms of cytokines, there was substantial increase in the level of IL-8, TNF-α, and IL-1 β in rats within I/R group (1.79 ± 0.39, 2.39 ± 0.53, and 1.12 ± 0.04, respectively) compared to those within the control group. However, the concentrations of these parameters were reduced in animal’s blood treated with Crataegus (1.36 ± 0.07, 1.78 ± 0.06, and 0.75 ± 0.09, respectively). Conclusions: These results suggest that the local Crataegus could protect rat brain tissues against ischemia-reperfusion-induced brain damage.

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    Author(s) Name:

    Mustafa Taha Mohammed1 *, Sura Mohammed Kadhim2 , Sura Mohsin Abbood1

    Affiliation(s) Name:

    1 Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq,

    2 Ministry of Education, Rusafa-1, Baghdad, Iraq

    *Corresponding author: Mustafa Taha Mohammed, Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq.

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    Author:

    Mustafa Taha Mohammed1 *, Sura Mohammed Kadhim2 , Sura Mohsin Abbood1

    Title:Study of some Crataegus leaves component and effect of their aqueous extract on oxidative stress during ischemia/ reperfusion brain damage
    Journal:Drug Invention Today
    Vol(issue):14 (May)
    Year:2020
    Page No: (718-721)
  • Experimental Methods Keywords

    Methodology:Antioxidant, Crataegus, Ischemia/reperfusion, Oxidative stress
    Research Materials:Crataegus leaves

Keywords

Antioxidant Crataegus Ischemia/reperfusion Oxidative stress

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