Journal: Drug Invention Today

Article Id: JPRS-TE-00005032
Title: Acute toxicity of ethanolic extract of hantap (Sterculia urceolata J. E. Smith) leaves
Category: Toxicity evaluation
Section: Research Article
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    Background: Hantap (Sterculia urceolata J. E. Smith), Malvaceae family, is widespread in Indonesia. Hantap leaves are empirically used to treat heartburn, thrush, flatulence, constipation, expectorants, hair cleanser, and tonic. There has been no scientific proof through the safety of hantap leaves ethanolic extracts. Aim: The purpose of this study was to determine the acute toxicity and toxic symptoms of hantap leaves ethanolic extracts. Materials and Methods: Acute toxicity assay was conducted by various concentrations of hantap leaves ethanolic extract (70, 700, 1400, 7000, and 21,000 mg/kg mice) on female Swiss Webster mice. The toxic symptoms were observed for 14 days. Results: The safety level of hantap leaves ethanolic extract was 6th category, i.e., relatively harmless, based on Hodge and Sterner toxicity scale. This extract has a significant effect on the central nervous system by reducing the effects of hanging (P = 0.010) and retablissement (P = 0.001). Conclusion: Hantap leaves were safe.

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    Author(s) Name:

    Nyi Mekar Saptarini*, Resmi Mustarichie

    Affiliation(s) Name:

    Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, West Java, Indonesia

    *Corresponding author: Nyi Mekar Saptarini, Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl Raya Bandung Sumedang Km 21, West Java 45363 Indonesia.

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    Author:

    Nyi Mekar Saptarini*, Resmi Mustarichie

    Title:Acute toxicity of ethanolic extract of hantap (Sterculia urceolata J. E. Smith) leaves
    Journal:Drug Invention Today
    Vol(issue):14 (May)
    Year:2020
    Page No: (729-732)
  • Experimental Methods Keywords

    Methodology: Acute toxicity studies
    Research Materials:hantap (Sterculia urceolata J. E. Smith) leaves

Keywords

Acute toxicity Hantap leaves Relatively harmless Safe

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