Journal: Drug Invention Today

Article Id: JPRS-TE-00005037
Title: Acute Toxicity of Extract of Sunan candlenut (Reutealis trisperma (Blanco) Airy Shaw) Seeds
Category: Toxicity evaluation
Section: Research Article
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    Background: Extract of Sunan candlenut (Reutealis trisperma (Blanco) Airy Shaw) seed, the Euphorbiaceae family, has been shown to have anti-alopecia activity. Extract safety must be determined so that the extract can be developed into herbal preparations. Aim: The purpose of this study was to determine the acute toxicity and toxic symptoms of Sunan candlenut seed extract. Materials and Methods: Acute toxicity assay was conducted on female Swiss Webster mice with various concentrations of Sunan candlenut seed extract (70, 700, 1400, 3500, and 7000 mg/kg BW mice), then observed the toxic symptoms for 14 days. Results: The LD50 value of Sunan candlenut seed extract was 4954 mg/kg BW mice. This extract has a significant effect on the central nervous system by reducing the motoric activity (P = 2 × 10-4) and retablisment (P = 0.002), and the autonomic nervous system by disturbing ptosis (P = 0.032) and breathing (P = 0.001). Conclusion: The Sunan candlenut seed extract was 6th category, i.e., relatively harmless, based on the Hodge and Sterner toxicity scale.

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    Author(s) Name:

    Nyi Mekar Saptarini*, Resmi Mustarichie

    Affiliation(s) Name:

    Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, West Java, Indonesia

    *Corresponding author: Nyi Mekar Saptarini, Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl Raya Bandung Sumedang km 21, West Java 45363 Indonesia.

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    Author:

    Nyi Mekar Saptarini*, Resmi Mustarichie

    Title:Acute Toxicity of Extract of Sunan candlenut (Reutealis trisperma (Blanco) Airy Shaw) Seeds
    Journal:Drug Invention Today
    Vol(issue):14 (May)
    Year:2020
    Page No: (753-756)
  • Experimental Methods Keywords

    Methodology:Acute toxicity, LD50 value, Relatively harmless, Toxic symptoms
    Research Materials:Sunan candlenut (Reutealis trisperma (Blanco) Airy Shaw) Seeds

Keywords

Acute toxicity LD50 value Relatively harmless Toxic symptoms

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