Journal: Drug Invention Today

Article Id: JPRS-MSNS-00005040
Title: Antibacterial efficacy of methanol extract of mango kernel against blood culture isolates of Salmonella Typhi
Category: Microbiological Study (on Natural/ Synthetic drug)
Section: Research Article
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    Introduction: The emergence of fluoroquinolone resistant Salmonella has become a serious public health concern. The antimicrobials of plant origin are considered as alternatives to synthetic drugs. Mango seed kernel has been used in Indian systems of medicine, Ayurveda for many years. Hence, this study was aimed to assess the antibacterial efficacy of the methanol extract of mango seed kernel against ciprofloxacin resistant and ciprofloxacin susceptible Salmonella Typhi isolates. Materials and Methods: The methanol extract of mango seed kernel was prepared by cold percolation method. S. Typhi (n = 48) isolated from the blood culture of patients with enteric fever were included in the study. Minimum inhibitory concentration (MIC) of the methanol extract of mango kernel and the standard antibiotic ciprofloxacin was assessed by broth microdilution method. Results: Of 48 clinical isolates of S. Typhi, 24 (50%) were intermediately susceptible to ciprofloxacin (MIC range: 0.24–0.5 µg/mL) while, 24 (50%) were resistant to ciprofloxacin (MIC range: 1 to >4 mg/mL). The methanolic extract of mango seed kernel displayed significant anti-salmonella activity. MIC50 and MIC90 of the methanolic extract of mango kernel was found to be >16 mg/mL. Conclusion: Among the 24 ciprofloxacin resistant isolates, 1 (4.2%), 5 (20.8%), and 1 (4.2%) isolates had mango seed kernel MIC of 8, 12, and 16 mg/mL, respectively. Of the 13 isolates with a higher ciprofloxacin MIC (>4 µg/mL), 5 (38.5%) were inhibited at a concentration of ≤12 mg/mL of methanol extract of mango kernel. Our results suggest mango kernel seed extract would serve as a better alternative for the effective treatment of invasive Salmonella infections.

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    Author(s) Name:

    Rajan Prabhurajan1,2 , Kesavaram Padmavathy1 *, R. Mary Esther Selvam3 , Jayamathi Govindaraj 4

    Affiliation(s) Name:

    1 Department of Microbiology, Research Laboratory for Oral and Systemic Health, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India,

    2 Department of Microbiology, Annapoorana Medical College and Hospital, Salem, Tamil Nadu, India,

    3 Department of Microbiology, ESIC Hospital, Chennai, Tamil Nadu, India,

    4 Department of Biochemistry, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India

    *Corresponding author: Kesavaram Padmavathy, Department of Microbiology, Research Laboratory for Oral and Systemic Health, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai - 600 100, Tamil Nadu, India

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    Author:

    Rajan Prabhurajan1,2 , Kesavaram Padmavathy1 *, R. Mary Esther Selvam3 , Jayamathi Govindaraj 4

    Title:Antibacterial efficacy of methanol extract of mango kernel against blood culture isolates of Salmonella Typhi
    Journal:Drug Invention Today
    Vol(issue):14 (May)
    Year:2020
    Page No: (765-768)
  • Experimental Methods Keywords

    Methodology:Antibacterial efficacy
    Research Materials:mango kernel

Keywords

Ciprofloxacin resistance Mango kernel Salmonella Typhi

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