Journal: Drug Invention Today

Article Id: JPRS-Other-00005048
Title: Preparation and characterization of graphene oxide for biological application
Category: Others ( DIT Related Science )
Section: Research Article
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    Background: Graphene oxide (GO) has a big surface area, moral dispersibility in solvents, and a great aspect ratio. GO displays antimicrobial activity and raise the bioavailability of adsorbed antibiotics. This investigation was aimed to create GO from graphite by simple method and detection of its antimicrobial action and cytotoxicity against lung cancer. Materials and Methods: GO was created by Hummer’s way. The synthesis of GO was shown by many characterizing techniques: Ultraviolet, Raman, X-ray diffraction, scanning electron microscope, and detection of its antioxidant, antibacterial, anti-parasitic action, and cytotoxicity against lung cancer. Results: GO offered the higher result against Staphylococcus aureus and Escherichia coli with inhibition zone 22 mm while Pseudomonas aeruginosa, 20 mm and Candida albicans, 19 mm. The antimicrobial action of GO offered higher results compare with antibiotics. The antioxidant action of GO was estimated through the 1,1-diphenyl-2-picrylhydrazyl assay, and the outcomes were displayed 42% in 75 μg/ml concentration. The anticancer activity of GO was examined against lung cancer (A549). The outcome indicated a good level of cytotoxic activity in 50 and 100 μg/mL concentration. The antiparasite action of GO against Leishmania tropica was estimated by MTT assay and the high concentration that causes cytotoxic 10 mg/ml (63%). Conclusion: This investigation concludes the good ability to GO for biological application.

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    Author(s) Name:

    Raghad Khwater Maeh1 *, Ahmed Issa Jaafar2 , Butheina Abd Al-Hamza Hasoon1 , Nehia Neama Hussein1

    Affiliation(s) Name:

    1 Department of Applied Sciences, University of Technology, Baghdad, Iraq,

    2 Department of Basic Sciences, College of Dentistry, Al-Iraqia University, Baghdad, Iraq

    *Corresponding author: Raghad Khwater Maeh, Department of Applied Sciences, University of Technology, Baghdad, Iraq.

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    Author:

    Raghad Khwater Maeh1 *, Ahmed Issa Jaafar2 , Butheina Abd Al-Hamza Hasoon1 , Nehia Neama Hussein1

    Title:Preparation and characterization of graphene oxide for biological application
    Journal:Drug Invention Today
    Vol(issue):14 (May)
    Year:2020
    Page No: (799-805)
  • Experimental Methods Keywords

    Methodology:Antimicrobial, Anticancer, Antioxidant, Hummer’s method
    Research Materials:Graphene oxide,

Keywords

Antimicrobial Anticancer Antioxidant Graphene oxide Hummer’s method

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