Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-000051
Title: Formulation and evaluation of controlled release matrix tablets of Pentoxifylline
Category: Pharmaceutics
Section: Research Article
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    Pentoxifylline is a vasodilator widely used in the treatment of the peripheral & cerebral vascular disorders & thus exerts a milder side effect on gastrointestinal mucosa. The objective of this work is two retardant polymers were employed with varying concentrations & also in combination in different ratio to get promising concentration for controlled release matrix tablets. Matrix tablets of pentoxifylline were formulated using hydrophilic swellable polymers hydroxyl propyl methyl cellulose & guar gum with lactose as diluent. Two retardant polymers HPMC & guar gum were used in different ratio to retard the drug release from the matrices. Talc, magnesium Stearate& starch were used as excipients. All the formulations prepared were found to comply with the weight variation, friability, drug content uniformity & in-vitro dissolution studies. Promising formulations F3, F6, F8 were compared with marketed formulation, which shows that formulation F3 exhibits drug release pattern which is similar with marketed formulation of pentoxifylline.

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    Author(s) Name:

    J.Jeya Ananthi*, Umesh Chourasia, A.Lakshmi, M.B. Viswanathan1

    Affiliation(s) Name:

    *Dept. of Pharmaceutics,Arulmigu Kalasalingam college of Pharmacy, Krishnankoil-626 190. Tamil Nadu, India
    1Dept. of Plant Science, Bharathidasan University, Trichy – 21


    For correspondence:J.Jeya Ananthi,Dept. of Pharmaceutics,Arulmigu Kalasalingam college of Pharmacy, Krishnankoil- 626 190. Tamil Nadu, India.
    E-mail: jeyaananthi2005@yahoo.co.in


    Received on:08-08-2008; Accepted on :04-10-2008

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    Author:

    J.Jeya Ananthi*, Umesh Chourasia, A.Lakshmi, M.B. Viswanathan1

    Title:Formulation and evaluation of controlled release matrix tablets of Pentoxifylline
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (January )
    Year:2009
    Page No: (18-21)
  • Experimental Methods Keywords

    Methodology:Formulation and evaluation of controlled release matrix tablets
    Research Materials:Pentoxifylline

Keywords

Pentoxifylline Vasodilator Controlled release Matrix tablets

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