Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00005136
Title: Inlay tablet of Atorvastatin calcium with sustained release Metoprolol tartarate
Category: Pharmaceutics
Section: Research Article
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  • Abstract

    The objective of this study was to design a dual retard technique of once daily Inlay tablet of Atorvastatin calcium as Immediate Release (IR) formulation with Matrix tablet of Metoprolol tartarate as Sustained release (SR) formulation for Hypertension and Atherosclerosis. The Inlay tablet was prepared by Wet granulation method. The Compatibility of the drug with various excipients was studied by Differential scanning calorimetry (DSC). The formulations were developed by using polymers like Guar gum, Eudragit, HPMC for sustained release layer and Sodium starch glycolate, Cross povidone, Cross carmellose sodium as Super disintegrants for immediate release layer. Six formulations (F1-F6) were prepared and evaluated for various parameters like Thickness, Hardness, Weight variation, Disintegration, Swelling Erosion behavior, Simultaneous analysis by both UV and HPLC, In vitro release and Stability studies at 40º±2ºC, RH 70±5%. Among the six formulations (F1-F6), F4 possess expected release pattern in both immediate release layer and sustained release layer. Further from the Release kinetics it was revealed that the drug release for formulation F4 follows Zero order. Thus the study concludes that the formulation can overcome the disadvantages of other multilayered tablets and can be used to treat the patients having high blood pressure with Hyperlipidemia that plays major risk factors for CHD.

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    Author(s) Name:

    S.Brito Raj 1 *, E.Mohanambal 2 , K.Reeta Vijaya Rani 1 , S.Wasim Raja4 , M.Antoshering3

    Affiliation(s) Name:

    1 Department of Pharmaceutics, Periyar college of Pharmaceutical sciences, Trichirappalli-620 021, TN, India.

    2 Department of Pharmaceutics, Sri Venkateswara college of Pharmacy, R.V.S. Nagar, Chittoor, AP, India.

    3 Research Associate, Medisas Pharmaceuticals, Puducherry, India.

    4 Department of Pharmacy Practice, Periyar college of Pharmaceutical sciences, Trichirappalli-620 021, TN, India.

    *Corresponding author. S.Brito Raj, M.Pharm, Department of pharmaceutics, Periyar college of Pharmaceutical sciences, Trichirappalli-620 021, Tamil nadu, India

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    Author:

    S.Brito Raj 1 *, E.Mohanambal 2 , K.Reeta Vijaya Rani 1 , S.Wasim Raja4 , M.Antoshering3

    Title:Inlay tablet of Atorvastatin calcium with sustained release Metoprolol tartarate
    Journal:Journal of Pharmacy Research
    Vol(issue):11 (April)
    Year:2017
    Page No: (3585-3589)
  • Experimental Methods Keywords

    Methodology:Differential scanning calorimetry (DSC)
    Research Materials:Metoprolol tartarate

Keywords

Inlay tablet Matrix tablet Hydroxypropyl methylcellulose Metoprolol tartarate Atorvastatin calcium Hypertension.

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