Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-0000519
Title: Anti-asthmatic activity of methanolic extract of leaves of Tamarindus Indica Linn.
Category: Pharmacology
Section: Research Article
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  • Abstract

    Tamarindus indica Linn. (Caesalpiniaceae), is a medicinal plant, used in folk medicine for treating asthma, dysentery, vaginal and uterine complaints, inflammation and variety of other condition. In this study methanolic extract of leaves of Tamarindus indica Linn at the doses of 175, 350 and 700 mg/kg, p.o., exhibited significant (p<0.01) mast cell stabilizing activity against clonidine induced mast cell degranulation in rats and significantly inhibited (p<0.01) the milk induced leucocytes and eosinophilia in mice. Clonidine, a α2 adrenoreceptors agonist induces dose dependent catalepsy in mice, which is inhibited by histamine H1 receptor antagonists. Prior treatment with methanolic extract of Tamarindus indica Linn at the dose of 250, 500 and 1000 mg/kg, p.o., significantly inhibited (p<0.01) the clonidine-induced catalepsy in mice. Thus the present study revealed that the methanolic extract of leaves of Tamarindus indica Linn exhibited significant antihistaminic, adaptogenic and mast cell stabilizing activity in the laboratory animals.

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    Author(s) Name:

    Tayade P.M.1*, Ghaisas M.M. Jagtap S.A. Dongre S.H.

    Affiliation(s) Name:

    1 Department of Pharmacology, Yash Institute of pharmacy, South City, Bajaj Nagar,
    Aurangabad.Maharastra,India
    2Dr. D.Y. Patil Institute of Pharmaceutical Science and Research, Pimpri, Pune.Maharastra, India


    Received on: 05-09-2008; Accepted on:26-01-2009

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    Author:

    Tayade P.M.1*, Ghaisas M.M. Jagtap S.A. Dongre S.H.

    Title:Anti-asthmatic activity of methanolic extract of leaves of Tamarindus Indica Linn.
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (May)
    Year:2009
    Page No: (944-947)
  • Experimental Methods Keywords

    Methodology:Catalepsy, Antihistaminic, Adaptogenic.
    Research Materials:Tamarindus indica

Keywords

Asthma Tamarindus indica Catalepsy Antihistaminic Adaptogenic.

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