Journal: Drug Invention Today

Article Id: JPRS-BRPT-00005257
Title: Biofilm inhibitory activity of plant-derived antioxidant compounds among Staphylococcus epidermidis obtained from clinical samples
Category: Biotechnology & Related Pharmaceutical Technology
Section: Research Article
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    Introduction and Aim: Bacteria synthesize their hydrated polymeric matrix that attaches to various surfaces, which allows them to aggregate and form sessile communities. Many active compounds derived from various natural sources are found to be effective against biofilms, because of their anti-inflammatory, antibacterial, antioxidant, and anti-biofilm properties. Materials and Methods: A total of 35 isolates of Staphylococcus epidermidis which showed biofilm formation were obtained from various sites such as skin, mucosal membrane, invasive devices, and from the blood. Among these 35 isolates, eight strains were strong biofilm producers by tissue culture plate method, which were considered for this study. The minimum biofilm inhibitory concentration (MBIC) assay was carried out on the seven S. epidermidis isolates, with four different active compounds using various concentrations. Results: Analysis was performed with the MBIC values of quercetin, boswellic acid (BA), thymoquinone, and lycopodium. Out of these four compounds, BA showed the MBIC values with 7 × 10-5 mM, 1.75 × 10-5 mM, 1.7 × 105 mM, and 0.0001401 mM, respectively. Conclusion: The biofilm susceptibility assay results showed a high rate of biofilm inhibition by BA, followed by thymoquinone, lycopodium, and quercetin.

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    Author(s) Name:

    Diptimayee Das1 , Vasanthi Rompicherla2 *, J. Perummal 2 , R. Murugesan2 , Priyadarshini Shanmugam2

    Affiliation(s) Name:

    1 Department of Medical Biotechnology, Chettinad Academy of Research and Education, Chennai, Tamil Nadu, India,

    2 Department of Microbiology, Chettinad Academy of Research and Education, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. Vasanthi Rompicherla, Department of Microbiology, Chettinad Academy of Research and Education, Chennai - 600 119, Tamil Nadu, India.

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    Author:

    Diptimayee Das1 , Vasanthi Rompicherla2 *, J. Perummal 2 , R. Murugesan2 , Priyadarshini Shanmugam2

    Title:Biofilm inhibitory activity of plant-derived antioxidant compounds among Staphylococcus epidermidis obtained from clinical samples
    Journal:Drug Invention Today
    Vol(issue):14 (June )
    Year:2020
    Page No: (1248-1253)
  • Experimental Methods Keywords

    Methodology:Biofilm inhibitory activity
    Research Materials:Boswellic acid, Lycopodium, Quercetin, Thymoquinone

Keywords

Boswellic acid Lycopodium Quercetin Thymoquinone

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