Journal: Journal of Pharmacy Research

Article Id: JPRS-ADRS-000053
Title: Studies on effect of co-administration of Trikatu and its components on oral bioavailability of Ampicillin and Norfloxacin, in rabbits
Category: Ayurvedic Drugs Related Study
Section: Research Article
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    Ampicillin and Norfloxacin are used to treat variety of Bacterial infections in Humans. These two drugs possess poor oral bioavailability as found from literatures. Ayurvedic literatures deal with the enhancement of oral bioavailability by TRIKATU (mixture of alcoholic extracts of dried fruits of Piper longum, dried fruits of Piper nigrum and dried rhizomes of Zingiber officinalis) or by its components. The study was aimed to find out the efficacy of TRIKATU or its components in enhancing bioavailability of the above antibiotics. The extracts of components of TRIKATU were prepared by soxhlation using alcohol (90%). The study was carried out in rabbits by oral administration of the extracts of the components and their combination in equal proportions (TRIKATU) along with above antibiotics. Blood samples were drawn at time intervals equal to three half – lives of the antibiotics and their plasma concentrations were estimated microbiologically. TRIKATU and its components enhanced the Bioavailability of Ampicilin, but the components produced no effect on Norfloxacin’s Bioavailability. Trikatu has shown maximal enhancement for both antibiotics.

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    Author(s) Name:

    Kunchithapatham Janakiraman*1 and Rajappan Manavalan1

    Affiliation(s) Name:

    1Department of Pharmacy, Annamalai University, Annamalainagar, Tamil Nadu, India

    For correspondence:Kunchithapatham Janakiraman et al.,Lecturer, Department of Pharmacy, Annamalai University, Annamalainagar, Tamil Nadu, India.


    E-mail: janakiraman_k06@yahoo.co.in.

    Received on:13-07-2008; Accepted on :05-11-2008

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    Author:

    Kunchithapatham Janakiraman*1 and Rajappan Manavalan1

    Title:Studies on effect of co-administration of Trikatu and its components on oral bioavailability of Ampicillin and Norfloxacin, in rabbits
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (January )
    Year:2009
    Page No: (27-30)
  • Experimental Methods Keywords

    Methodology:Bioavailability,
    Research Materials:TRIKATU,Ampicillin, Norfloxacin

Keywords

TRIKATU Bioavailability Ampicillin Norfloxacin

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