Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000532
Title: Development and Evaluation of Polysaccharide Based Matrix Tablets of Celecoxib for Colonic Delivery
Category: Pharmaceutics
Section: Research Article
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    The main objective behind present investigation was development of more appropriate oral colon-specific formulation of celecoxib (COX-II inhibitor, drug which is reported in treatment of colon polyps) using the polysaccharides like gellan gum, pectin and guar gum. The matrix tablets were prepared by wet granulation method using starch paste as binder. The granules were evaluated for angle of repose, Carr’s index, porosity, drug content. Three month stability study, IR and DSC study were done for evaluation of chemical interaction and melting and crystallization endotherm deflection of drug in formulation. Tablets were evaluated for thickness, hardness, drug content, friability and in vitro drug release studies in SGF, SIF and SCF. Optimized formulation was in vivo evaluated by Roentgenography technique. It was found that native gellan gum and combination with pectin based matrix tablets are not appropriate in colon-specific formulations that might be because of highacyl gellan gum and water loving properties of gellan gum and pectin. The combination gellan gum and guar gum (1:1) is found to be suitable as they released the drug only 10.77 % in upper gastrointestinal tract and 98.85% drug released was after 24 hours dissolution study. Result of stability study showed that there is no degradation of celecoxib with gellan gum and guar gum. IR & DSC study suggest that no chemical interaction of celecoxib with gellan gum, guar gum and pectin and no change in crystallization endotherm (Tc) and melting endotherm (Tm) of celecoxib. The in vivo study of optimized formulation showed that matrix tablet formulation passes after two hour from stomach and after six hour from the small intestine without considerable physical changes of the tablet. Third and fourth reading of Roentgenography suggest that the tablet releases the drug for prolong time in colon.

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    Author(s) Name:

    Dhaval Patel*,S.D.Barhathe, Dr.J.K.Patel

    Affiliation(s) Name:

    a*Department of Pharmaceutics, Smt. S. S. Patil College of Pharmacy Chopda-425 107 (M.S.)
    Department of Pharmaceutics, Nootan college of pharmacy,visnagar.N.Gujarat


    Received on: 24-12-2008; Accepted on: 07-03-2009

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    Author:

    Dhaval Patel*,S.D.Barhathe, Dr.J.K.Patel

    Title:Development and Evaluation of Polysaccharide Based Matrix Tablets of Celecoxib for Colonic Delivery
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (June)
    Year:2009
    Page No: (1022-1025)
  • Experimental Methods Keywords

    Methodology:Development and Evaluation
    Research Materials:Celecoxib

Keywords

Development ;Evaluation ;Polysaccharide Based Matrix Tablets; Celecoxib ; Colonic Delivery

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