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Abstract

The antidiabetic effect of methanolic extract of whole plant of Cleome aspera was investigated in Streptozotocin induced type 2 diabetic rats. The C. aspera showed a dose dependent hypoglycemic effect and prevented rise in blood glucose levels in diabetic rats. The blood glucose levels were measured at 0, 2, 4, 6 and 8 h after the treatment. The methanolic extract of C. aspera at a doses of 100, 200 and 400 mg/kg body weight (b.w.) reduced the blood glucose levels of the normal rat from 75.29±6.4 to 68.18±6.59 mg/dl, 87.19±5.1 to 71.28±7.45 mg/ dl and 85.45±7.6 to 68.16±7.45 respectively at 6 h after oral administration of the extract (P<0.05) and also significantly lowered blood glucose levels in Streptozotocin induced diabetic rats from 238.62±9.60 to 176.96± 6.40 mg/dl at 4h after oral administration of the 400 mg/kg b.w. extract (P<0.05). In glucose tolerance test, extract markedly reduced the external glucose load. The antihyperglycemic activity of C. aspera was compared with glibenclamide (10 mg/kg), an oral hypoglycemic agent. The above results suggest that C. aspera is a potent antidiabetic agent.

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