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Abstract

The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid precorneal elimination of the drug may be overcome by use of in –situ gel forming system that are instilled as a drops into the eye and it undergoes a sol-gel transition in the cul-de-sac. The present work describes the formulation and evaluation of an ophthalmic delivery system of an antibacterial agent, ciprofloxacin, which is used in the treatment of eye infection such as dacrocystitis, bacterial conjunctivitis, corneal ulceration and blepharitis, based on the concepts of pH-triggered in-situ gelation, thermo reversible gelation and Ion activated system. Poly acrylic acid (Carbopol 940) was used as the gelling agent in combination of hydroxy propyl methylcellulose, which acted as a viscosity-enhancing agent. (pH-triggered system). Pluronic F-127 (14%) was used as the thermal reversible gelation in combination of HPMC (1.5%) incorporation of HPMC was to reduce the concentration of pluronic required for in-situ gelling property, with 25% w/w pluronic F-127 reported to form good gels. Gellan gum (Gelrite) is an anionic exocellular polysaccharide by the bacterium pseudo Monas elodea, having the characteristic property cation-induced gelation (0.6%). The developed formulation was therapeutically efficacious, stable, non irritant and provided sustained release of the drug over an 6 hours period, but Gelrite formulation showing long duration of release followed by combination of carbopol, HPMC and pluronic F-127 & HPMC. The developed system is thus a viable alternative to conventional eye drops.

Cite this article as:EC Mohan, JM KanduKuri, V Allenki,Preparation and Evaluation of In-Situ-Gels for Ocular Drug Delivery Journal of Pharmacy Research 2009, 2 (6), 1089-1094.

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	JPR Solutions

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