Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000546
Title: Formulation and optimization of controlled released floating matrix tablets of cefixime
Category: Pharmaceutics
Section: Research Article
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    The purpose of this research was to prepare a floating drug delivery system of Cefixime trihydrate (Cefixime). Floating matrix tablets of Cefixime were developed to prolong gastric residence time, increase its bioavailability and patient compliance. Rapid gastro-intestinal transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to diminished efficacy of the administered dose. The tablets were prepared by direct compression technique, using polymers such as HPMC K 100 LV, HPMC K4M, HPMC K15M and HPMC K100M, alone or in combination and other standard excipients. Sodium bicarbonate was incorporated as a gas generating agent and citric acid was incorporated as a release rate enhancer. The effect of Sodium bicarbonate, tablet hardness and content of citric acid on drug release profile and floating properties were investigated. A 32 full factorial design was applied to systematically optimize the drug release profile. The ratio of HPMC K4M to HPMC K100 LV (X1) and content of citric acid (X2) were selected as independent variables. The time required for 50 % (t50), percentage drug release at 12 hr (Q12), release rate constant (k) and diffusion exponent (n) were selected as dependent variables. The results of factorial design indicated that ratio of HPMC K4M to HPMC K100LV had dominant role on drug release from floating matrix tablets compared to citric acid, although the presence of later component in formulation with optimum concentration is essential to improve the drug release of hydrophobic molecules of drug. The linear regression analysis and model fitting showed that all these formulations followed Korsmeyer and Peppas model, which had a higher value of correlation coefficient (r).

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    Author(s) Name:

    Manish P. Patel*, Dr. Madhabhai M. Patel2, Dr. Krishnakumar N. Patel1

    Affiliation(s) Name:

    *1 Department of Pharmaceutics and Pharmaceutical Technology,Arihant School of Pharmacy and Bioresearch Institute, Adalaj-382421, S. G. Highway,Gandhinagar, Gujarat,India
    2 Department of Pharmaceutics and Pharmaceutical Technology, Kalol Institute of Pharmacy, Kalol -382721. Gujarat. India.


    Received on: 14-01-2009; Accepted on: 24-03-2009

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    Author:

    Manish P. Patel*, Dr. Madhabhai M. Patel2, Dr. Krishnakumar N. Patel1

    Title:Formulation and optimization of controlled released floating matrix tablets of cefixime
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (June)
    Year:2009
    Page No: (1110-1112)
  • Experimental Methods Keywords

    Methodology:Formulation and optimization
    Research Materials:Cefixime

Keywords

Cefixime HPMC K 100 LV HPMC K4M HPMC K15M and HPMC K100M

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