Journal: Journal of Pharmacy Research
Title: Formulation and Evaluation of Satranidazole Microspheres For Colon Targeted Drug Delivery
Category: Pharmaceutics
Section: Research Article
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Abstract
The purpose of this research was to develop and evaluate Eudragit based microspheres exploiting pH sensitivity property and specific biodegradability for colon targeted delivery of Satranidazole. Eudragit based microspheres were prepared by oil-in-oil solvent evaporation method using different drug- polymer ratios (1:1 to 1:5), stirring speeds (1200-1400 rpm) and emulsifier concentrations (0.5%-1.0% wt/vol). Differential scanning calorimetry, study of the physical mixtures of drug and polymer revealed no drug-polymer interaction. All formulations were evaluated for particle size and shape, swellability and percentage drug entrapment. The yield of preparation and the encapsulation efficiencies were high for all Eudragit microspheres. The in vitro drug release study of optimized formulation was also performed in simulated gastrointestinal fluids (SGF). The release profile of satranidazole from Eudragit microspheres was pH dependent. In acidic medium, the release rate was much slower; however, the drug was released quickly at pH 7.4. It is concluded from the present investigation that Eudragit microspheres are promising controlled release carriers for colon-targeted delivery of satranidazole.
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About the authors and Affiliations
Author(s) Name: Dinesh Chandra*1,Indranil Kumar Yadav2, Durga Jaiswal2, Niladry Ghosh2, Hari Pratap Singh3, Aushutosh Mishra3, Arundhati Bhattacharya1, Meenakshi Bajpai1 and D.A. Jain4
Affiliation(s) Name: 1.Division of Pharmaceutical Research, Raj Kumar Goel Institute of Technology, Ghaziabad-201003, India
2.Rajiv Gandhi College of Pharmacy, Nautanwa, Maharajganj-273164, India.
3.A.N.D. College of Pharmacy. Babhnan, Gonda- 271313, India.
4. Institute of Pharmacy, Bhagwant University- Ajmer, India
Received on: 27-02-2009; Accepted on: 29-04-2009-
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Author: Dinesh Chandra*1,Indranil Kumar Yadav2, Durga Jaiswal2, Niladry Ghosh2, Hari Pratap Singh3, Aushutosh Mishra3, Arundhati Bhattacharya1, Meenakshi Bajpai1 and D.A. Jain4
Title: Formulation and Evaluation of Satranidazole Microspheres For Colon Targeted Drug Delivery Journal: Journal of Pharmacy Research Vol(issue): 2 (July) Year: 2009 Page No: (1230-1233) -
Experimental Methods Keywords
Methodology: Formulation and Evaluation Research Materials: Satranidazole Microspheres
Keywords
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