Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000567
Title: Estimation of cefixime and ornidazole in its pharmaceutical dosage form by spectrophotometric method
Category: Pharmaceutics
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  • Abstract

    Two accurate, precise, rapid and economical methods were developed for the estimation of Cefixime and Ornidazole in tablet dosage form. First method is first order derivative spectroscopy, wavelengths selected for quantitation were 311.5 nm for Cefixime (zero cross for Ornidazole) and 290.0 nm for Ornidazole (zero cross for Cefixime). Second method is area under curve method; area under curve in the range of 295.0-285.0 nm (for Cefixime) and 317.0-307.0 nm (for Ornidazole) were selected for the analysis. In both the methods linearity for detector response was observed in the concentration range of 10-50 μg/ml for both, Cefixime and Ornidazole. The proposed methods were successfully applied for the simultaneous determination of both drugs in commercial tablet preparation. The results of the analysis have been validated statistically and by recovery studies.

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    Author(s) Name:

    *Ravindra Kumar Nanda, Jagdish Gaikwad and Anand Prakash.

    Affiliation(s) Name:

    Pad. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Sant Tukaram Nagar, Pimpri, Pune-18.


    Received on:12-03-2009; Accepted on: 26-05-2009

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    Author:

    *Ravindra Kumar Nanda, Jagdish Gaikwad and Anand Prakash.

    Title:Estimation of cefixime and ornidazole in its pharmaceutical dosage form by spectrophotometric method
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (July)
    Year:2009
    Page No: (1264-1266)
  • Experimental Methods Keywords

    Methodology:spectrophotometric method
    Research Materials:Cefixime

Keywords

Cefixime; Ornidazole; derivative spectroscopy; area under curve method

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