Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000586
Title: Evaluation of seed mucilage of Vigna mungo (L.) as a binder in tablet formulations
Category: Pharmaceutics
Section: Research Article
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  • Abstract

    The present work reports extraction of seed mucilage of Vigna mungo. Physiochemical characterization such as swelling index, hydration capacity, powder porosity, loss on drying, pH and viscosity were studied. The seed mucilage of Vigna mungo has been evaluated for its granulating and binding properties in tablets, using paracetamol as a model drug. The seed mucilages of Vigna mungo was used in four different concentrations- 2.5, 5.0, 7.5 and 10%w/w. The granules were prepared by wet granulation technique. The prepared granules were evaluated for percentage of fines, average particle size, compressibility index and flow properties. The properties were compared with starch, which was used as a standard binder at 10% w/w concentration. The tablets were prepared and evaluated for hardness, friability, content uniformity, disintegration time and in vitro dissolution profiles. They had good physicochemical properties, and the drug release was more than 80% within 2h. All the formulations (F1, F2, F3, and F4) were subjected to stability studies for three months at 40°C temperature and with RH 75±5%, only F1 and F2 showed stability with respect to release pattern and other parameters. Hence, 2.5% and 5% concentrations of mucilage of Vigna mungo can be considered as ideal concentrations for preparation of tablets.

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    Author(s) Name:

    Indranil KumarYadav *1, Durga Jaiswal1, Hari Pratap Singh2, Dinesh Chandra3 and D.A. Jain3

    Affiliation(s) Name:

    1.Rajiv Gandhi College of Pharmacy, Nautanwa, Maharajganj, India
    2.A.N.D. College of Pharmacy, Babhanan, Gonda, India
    3.Institute of Pharmaceutical Sciences and Research Centre, Bhagwant University Ajmer-305001, India.


    Received on: 09-04-2009; Accepted on: 26-06-2009

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    Author:

    Indranil KumarYadav *1, Durga Jaiswal1, Hari Pratap Singh2, Dinesh Chandra3 and D.A. Jain3

    Title:Evaluation of seed mucilage of Vigna mungo (L.) as a binder in tablet formulations
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (August)
    Year:2009
    Page No: (1281-1283)
  • Experimental Methods Keywords

    Methodology:Evaluation of seed mucilage
    Research Materials:Vigna mungo

Keywords

Vigna mungo Binder Paracetamol tablet Drug release.

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