Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000593
Title: Formulation and in-Vitro evaluation of mesalamine matrix tablets using chitosan for colonic drug delivery
Category: Pharmaceutics
Section: Research Article
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    The objective of the present study is to develop colon targeted drug delivery system by using Chitosan as a carrier for Mesalamine. Matrix tablets containing various excipients and Chitosan were prepared by wet granulation technique using different binder systems. The prepared tablets were evaluated for Hardness, Weight variation, Drug uniformity, Friability and In-vitro Drug release study. The surface of the device of best formulation was coated with Eudragit S100 to ensure that the device was more pH dependent and trigger the drug release only at higher pH. The final product is expected to have the advantage of being biodegradable and pH dependant. The matrix tablet containing Chitosan as a carrier and Hydroxypropyl methyl cellulose as binder was found to be suitable for targeting mesalamine for local action in the colon as compare to other matrix tablets containing different binders. Matrix tablets containing Chitosan released 97-99% of mesalamine in simulated colonic fluid. The stability study for prepared tablets at 40oC/75% relative humidity for three months showed no significant change in In-vitro drug release pattern. The results of in-vitro study indicate that matrix tablets containing Chitosan as carrier and Hydroxypropyl methyl cellulose as binder are most suitable to deliver the drug specifically in colonic region. The final formulation of mesalamine for colonspecific drug delivery gives pH, time and enzyme controlled release.

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    Author(s) Name:

    Patel Jayvadan K.1 , Patel Nirav V. *, Shah Shreeraj H.2

    Affiliation(s) Name:

    1 Department of Pharmaceutics, Nootan Pharmacy College, Visnagar, Gujarat - 384 315, India
    * Department of Pharmaceutics,Anand Pharmacy College, Anand, Gujarat – 388 001, India
    2Department of Pharmaceutics, L. J. Institute of Pharmacy, Ahmedabad, Gujarat – 382 210, India


    Received on: 07-04-2009; Accepted on: 09-05-2009

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    Author:

    Patel Jayvadan K.1 , Patel Nirav V. *, Shah Shreeraj H.2

    Title:Formulation and in-Vitro evaluation of mesalamine matrix tablets using chitosan for colonic drug delivery
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (August)
    Year:2009
    Page No: (1319-1323)
  • Experimental Methods Keywords

    Methodology:Formulation and in-Vitro evaluation
    Research Materials:Mesalamine

Keywords

Mesalamine Matrix tablet Chitosan Hydroxypropyl methyl cellulose Eudragit S100 Colon Specific drug delivery.

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