Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000594
Title: Formulation of bilayer tablet containing metoprolol succinate and amlodipine besylate as a model drug for antihypertensive therapy
Category: Pharmaceutics
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    The purpose of the present work was to develop an optimized bilayer tablet for antihypertension patients using Metoprolol succinate and Amlodipine besylate as a model drug candidate by optimization technique. A 32 factorial design was employed in formulating bilayer tablet with individual release layer i.e. sustained release layer and immediate release layer. The independent variables selected both cases HPMC(X1), Starch 1500 (X2) and SSG (X1), MCC (X2), respectively. Two dependent variables were considered: t50 (Y1), Q12 (Y2) and t50 (Y1), Q2 (Y2), respectively. The main effect and interaction terms were quantitatively evaluated using mathematical model. Bilayer tablets were evaluated for thickness, hardness, friability, drug content and in vitro dissolution studies. The drug release of Amlodipine besylate and Metoprolol succinate depicted non-fickian diffusion and Super Case II transport mechanism, respectively.

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    Author(s) Name:

    Atram SC*., Udavant YK., Salunke RJ., Neb GB., Shahi SR., Gulecha BS., Padalkar AN

    Affiliation(s) Name:

    *Government College of Pharmacy, Aurangabad. 431005, India. (MS).


    Received on: 27-04-2009; Accepted on: 09-06-2009

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    Author:

    Atram SC*., Udavant YK., Salunke RJ., Neb GB., Shahi SR., Gulecha BS., Padalkar AN

    Title:Formulation of bilayer tablet containing metoprolol succinate and amlodipine besylate as a model drug for antihypertensive therapy
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (August)
    Year:2009
    Page No: (1335-1347)
  • Experimental Methods Keywords

    Methodology:Formulation of bilayer tablet, factorial design, non-fickian diffusion, super case II transport
    Research Materials:Metoprolol succinate and Amlodipine besylate

Keywords

Bilayer tablets factorial design non-fickian diffusion super case II transport

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