Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000595
Title: Preparation and characterization of ofloxacin non-ionic surfactant vesicles for ophthalmic use
Category: Pharmaceutics
Section: Research Article
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    Ofloxacin is a fluorinated 4-quinolone antibiotic which is used in the treatment of ophthalmic ailments like infections, inflammations, conjunctivitis, blepharitis, iritis, corneal ulcer etc. Commercially, ofloxacin eye drop solution is available and it is quite easy for the administration. However, the product has drawback of poor bioavailability due to several factors such as tear production, non-productive absorption, transient residence time, and impermeability of corneal epithelium. In order to improve the bioavailability, residence time and longer duration of action, an attempt was made to formulate the non ionic surfactant vesicle and characterized. In the present study, the nonionic surfactant vesicles were prepared by lipid film hydration method using span 60 and cholesterol with various molar ratios and characterized for entrapment efficiency, in-vitro drug release, surface charge, rheological character, physical stability, minimum inhibitory concentration, in-vivo drug release and ocular irritation were conducted. The span 60: cholesterol in molar ratio of 100:60 showed higher entrapment of drug and released 73.77 % at 10th h and the availability of drug in the aqueous humor was 4.373μg/ml (Cmax), confirmed by HPLC method. The histopathology study also confirmed the safe use of niosomes. Study may be concluded that the non-ionic surfactant vesicles formulated with span 60 and cholesterol in a molar ratio of 100:60 showed potential approach to improve the ocular bioavailability of ofloxacin for the prolonged period of time.

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    Author(s) Name:

    Vijay Prakash Pandey*1 , Karthikeyan Deivasigamani 2

    Affiliation(s) Name:

    *1Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Chidambaram, Tamil Nadu, India.
    2Department of Pharmaceutics, Nandha College of Pharmacy and Research Centre, Erode-638052, Tamil Nadu, India.


    Received on: 09-04-2009; Accepted on:06-06-2009

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    Author:

    Vijay Prakash Pandey*1 , Karthikeyan Deivasigamani 2

    Title:Preparation and characterization of ofloxacin non-ionic surfactant vesicles for ophthalmic use
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (August)
    Year:2009
    Page No: (1330-1334)
  • Experimental Methods Keywords

    Methodology:Niosomes, Ocular delivery, Preparation and characterization
    Research Materials:Ofloxacin

Keywords

Niosomes Ocular delivery Ofloxacin

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