Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000597
Title: Preparation, physicochemical characterization, dissolution and formulation studies of irbesartan cyclodextrin inclusion complexes: Comparison between ß-CD & HP-ß-CD
Category: Pharmaceutics
Section: Research Article
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    Evaluation of inclusion complexes of irbesartan with ß-cyclodextrin and hydroxypropyl-ß-cyclodextrin, for dissolution properties and its tablet formulation were studied. Phase solubility curve was A L type for evaluation of stoichiometry. The prepared complexes were characterized by Fourier-transform infrared spectroscopy, differential scanning calorimetry and powder x-ray diffraction studies. The result of present findings clearly indicates maximum improvement in dissolution of irbesartan with the complex prepared with hydroxypropyl-ß-cyclodextrin with the kneading method. Various dissolution parameters point out the significant difference between the release profile of pure irbesartan and its complexes especially with hydroxypropyl-ß-cyclodextrin. The more hydrophilic nature of hydroxypropyl-ß-cyclodextrin might be responsible for better complexation and greater solubility of irbesartan. Even formulation studies too, the hydroxypropyl-ß-cyclodextrinirbesartan complex showed a better dissolution profile over ß-cyclodextrin.

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    Author(s) Name:

    Rajesh Kane1*, Suresh Naik1, Shrinivas Bumrela1, Bhanudas Kuchekar2.

    Affiliation(s) Name:

    1Sinhgad Institute of Pharmaceutical Sciences, Lonavala. Pune. Maharashtra, India.410 401
    2MIT’s Maharashtra Institute of Pharmacy,Erandavane, Pune. Maharashtra, India.


    Received on:26-04-2009; Accepted on: 13-06-2009

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    Author:

    Rajesh Kane1*, Suresh Naik1, Shrinivas Bumrela1, Bhanudas Kuchekar2.

    Title:Preparation, physicochemical characterization, dissolution and formulation studies of irbesartan cyclodextrin inclusion complexes: Comparison between ß-CD & HP-ß-CD
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (August)
    Year:2009
    Page No: (1359-1364)
  • Experimental Methods Keywords

    Methodology:Preparation, physicochemical characterization, dissolution and formulation studies
    Research Materials:irbesartan

Keywords

Irbesartan ß-cyclodextrin hydroxypropyl-ß-cyclodextrin inclusion complexes dissolution studies.

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