Journal: Journal of Pharmacy Research

Article Id: JPRS-HPh-0000598
Title: The world’s worst aquatic plant as a safe cancer medicine “Antitumor activity on melanoma induced mouse by Eichornia crassipes: in vivo studies”
Category: Hospital Pharmacy
Section: Research Article
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    Water hyacinth (Eichornia crassipes) is listed as one of the most productive plants on earth and is considered the world’s worst aquatic plant. Water hyacinths are a severe environmental and economic problem in all of the gulf coast states and in many other areas of the world with a sub-tropical or tropical climate. In spite of all these by our present study we can say “the worlds worst aquatic plant as a safe cancer medicine”. The in vivo growth response of a transplantable mouse melanoma with reference to 50% methanolic leaf extract of Eichornia crassipes (water hyacinth) was screened for its tumor inhibition potential by using B16F10 in vivo melanoma tumor bearing hybrid mice models (from Swiss albino female and C57BL male). The cell line was maintained in vivo in the department of research, Jawaharlal Nehru Cancer Hospital. Along with the standard diet the mice were treated with a daily oral dose of 200mg/kg body weight and 500mg/kg body weight of 50% methanolic extract Eichornia crassipes. On the other hand when these tumors has been subjected to herbal therapy followed by radio therapy, 4Gy in 3 fractions, revealed that the tumor inhibition is well appreciated by animal subjected to 500 mg/kg body weight followed by 200mg/kg body weight. The in vivo tumor regression was analyzed on day 1st-5th, 6 th-10th, 11th-16th and 17th-20th. The observations revealed that tumor volume of test groups decreased when compared with control groups.

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    Author(s) Name:

    Huma Ali 1*, Meha Patel3, N. Ganesh 1, and Janak Ahi2

    Affiliation(s) Name:

    1 Department of Research Jawaharlal Nehru Cancer Hospital& Research Center, Idgah,Hills,
    Bhopal 462001 India.
    2Department of Zoology, Dr. Hari Singh Gour University, Sagar, M.P India.
    3 Radha raman college of pharmacy, Bhopal. India.


    Received on: 07-03-2009; Accepted on: 29-05-2009

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    Author:

    Huma Ali 1*, Meha Patel3, N. Ganesh 1, and Janak Ahi2

    Title:The world’s worst aquatic plant as a safe cancer medicine “Antitumor activity on melanoma induced mouse by Eichornia crassipes: in vivo studies”
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (August)
    Year:2009
    Page No: (1365-1366)
  • Experimental Methods Keywords

    Methodology:Antitumor activity,in vivo studies
    Research Materials:Water hyacinth (Eichornia crassipes)

Keywords

Water hyacinth (Eichornia crassipes) Antitumor activity in vivo studies

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